老年男性2型糖尿病合并骨质疏松患者血清睾酮与胰岛素抵抗的相关性
Correlation of serum testosterone with insulin resistance in elderly male type 2 diabetes mellitus patients with osteoporosis.
作者信息
Xia Jin-Wei, Tan Shi-Jin, Zhang Xing-Liang, Jun Tao, Sun Xiao-Kang, Ling Wang
机构信息
Department of Geriatrics, the First Affiliated Hospital of Suzhou University Suzhou, China.
Department of Geriatrics, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shanghai, China.
出版信息
J Diabetes Investig. 2015 Sep;6(5):548-52. doi: 10.1111/jdi.12291. Epub 2015 Jun 15.
AIMS/INTRODUCTION: The present study was designed to investigate the correlations between the serum testosterone level and insulin sensitivity in elderly male type 2 diabetes patients with osteoporosis.
MATERIALS AND METHODS
A total of 35 elderly male patients with type 2 diabetes (type 2 diabetes group), 30 elderly male type 2 diabetes patients combined with osteoporosis (DO group) and 30 healthy elderly men (normal control group) participated in the present study. The fasting plasma glucose, fasting insulin, testosterone (T) and estradiol (E2) were measured. The insulin sensitivity index (ISI), homeostasis model assessment of insulin resistance (HOMA-IR) and E2/T were calculated. Then, the correlations of serum testosterone level with ISI and HOMA-IR were analyzed by statistical methods.
RESULTS
The HOMA-IR, E2 and E2/T of the type 2 diabetes group and DO group were significantly increased, whereas the bone mineral density, ISI, T and sex hormone binding globulin were decreased compared with those of the normal control group. Serum testosterone levels of the type 2 diabetes group and DO group were negatively correlated to the HOMA-IR (r = -0.496, -0.506; P < 0.05), whereas they were positively correlated to the fasting insulin (r = 0.281, 0.292; P < 0.05) and ISI (r = 0.364, 0.403; P < 0.05).
CONCLUSIONS
The reduced level of serum testosterone in elderly male type 2 diabetes patients with osteoporosis might promote insulin resistance.
目的/引言：本研究旨在调查老年男性2型糖尿病合并骨质疏松患者血清睾酮水平与胰岛素敏感性之间的相关性。
材料与方法
本研究共纳入35例老年男性2型糖尿病患者（2型糖尿病组）、30例老年男性2型糖尿病合并骨质疏松患者（糖尿病合并骨质疏松组）和30例健康老年男性（正常对照组）。测量空腹血糖、空腹胰岛素、睾酮（T）和雌二醇（E2）。计算胰岛素敏感性指数（ISI）、稳态模型评估胰岛素抵抗（HOMA-IR）和E2/T。然后，采用统计学方法分析血清睾酮水平与ISI和HOMA-IR的相关性。
结果
与正常对照组相比，2型糖尿病组和糖尿病合并骨质疏松组的HOMA-IR、E2和E2/T显著升高，而骨密度、ISI、T和性激素结合球蛋白降低。2型糖尿病组和糖尿病合并骨质疏松组的血清睾酮水平与HOMA-IR呈负相关（r = -0.496，-0.506；P < 0.05），而与空腹胰岛素（r = 0.281，0.292；P < 0.05）和ISI呈正相关（r = 0.364，0.403；P < 0.05）。
结论
老年男性2型糖尿病合并骨质疏松患者血清睾酮水平降低可能会促进胰岛素抵抗。
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