Krysta Krzysztof, Murawiec Sławomir, Warchala Anna, Zawada Karolina, Cubała Wiesław J, Wiglusz Mariusz S, Jakuszkowiak-Wojten Katarzyna, Krzystanek Marek, Krupka-Matuszczyk Irena
Department of Psychiatry and Psychotherapy, Medical University of Silesia, ul. Ziołowa 45/47, 40-635, Katowice, Poland,
Psychiatr Danub. 2015 Sep;27 Suppl 1:S435-7.
Opipramol is considered as a pharmacological agent that does not fit the classification taking into account the division of antidepressants, antipsychotics and anxiolytics. It has a structure related to tricyclic antidepressants but it has a different mechanism of action, i.e. binding to sigma1 and to sigma2 sites. It has been regarded as an effective drug in general anxiety disorders together with other agents like SSRIs, SNRIs, buspirone and pregabalin for many years. It can however also be indicated in other conditions, e.g. it may be used as a premedication in the evening prior to surgery, positive results are also observed in psychopharmacological treatment with opipramol in somatoform disorders, symptoms of depression can be significantly reduced in the climacteric syndrome. The latest data from literature present also certain dangers and side effects, which may result due to opipramol administration. Mania may be induced not only in bipolar patients treated with opipramol, but it can be an adverse drug reaction in generalized anxiety disorder. This analysis shows however that opipramol is an important drug still very useful in different clinical conditions.
奥匹哌醇被认为是一种不符合现有分类的药物，现有分类是基于抗抑郁药、抗精神病药和抗焦虑药的划分。它具有与三环类抗抑郁药相关的结构，但作用机制不同，即与σ1和σ2位点结合。多年来，它与其他药物如选择性5-羟色胺再摄取抑制剂（SSRI）、5-羟色胺及去甲肾上腺素再摄取抑制剂（SNRI）、丁螺环酮和普瑞巴林一起，被视为治疗广泛性焦虑症的有效药物。然而，它也可用于其他情况，例如，它可在手术前一晚用作术前用药，在躯体形式障碍的心理药物治疗中使用奥匹哌醇也观察到了积极效果，在更年期综合征中，抑郁症状可显著减轻。文献中的最新数据也表明了使用奥匹哌醇可能产生的某些危险和副作用。奥匹哌醇不仅可能诱发双相情感障碍患者的躁狂发作，在广泛性焦虑症中它也可能是一种药物不良反应。然而，该分析表明，奥匹哌醇是一种重要药物，在不同临床情况下仍然非常有用。
