通过 N-杂环卡宾催化的级联反应对双环 δ-内酰胺的对映选择性合成。
Enantioselective Synthesis of Bicyclic δ-Lactones via N-Heterocyclic Carbene-Catalyzed Cascade Reaction.
机构信息
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , 100190 Beijing, China.
出版信息
Org Lett. 2015 Oct 16;17(20):5140-3. doi: 10.1021/acs.orglett.5b02695. Epub 2015 Sep 29.
PMID:26418159
Abstract
The N-heterocyclic carbene-catalyzed cascade reaction of enals with malonates to give bicyclic δ-lactones was developed. The cyclopentane- and cyclohexane-fused δ-lactones with three continued stereocenters were obtained in high yields with excellent diastereo- and high enantioselectivities.
摘要
氮杂环卡宾催化烯醛与丙二酸盐的级联反应，生成双环 δ-内酰胺。高收率、高非对映选择性和高对映选择性地得到了具有三个连续手性中心的环戊烷和环己烷稠合的 δ-内酰胺。
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