Chen Xiang-Yu, Li Sun, Vetica Fabrizio, Kumar Mukesh, Enders Dieter
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
iScience. 2018 Apr 27;2:1-26. doi: 10.1016/j.isci.2018.03.006. Epub 2018 Apr 5.
Organocatalytic domino processes have become a rapidly growing area of research. N-heterocyclic carbenes (NHCs) have emerged as powerful organocatalysts for various transformations and continue to have widespread application. In the last decade, domino reactions catalyzed by NHCs have seen significant progress since the different activation modes could be successfully combined in one process. The most attractive features of these domino sequences include the readily available catalysts and substrates, the simple operational procedures, and the rapid assembly of complex molecular scaffolds with excellent levels of stereocontrol under mild reaction conditions. This review covers the advances in NHC-catalyzed domino reactions by focusing on the reaction scope, limitations, and mechanism with a close attention to the features of the reaction substrates.
有机催化多米诺反应已成为一个快速发展的研究领域。N-杂环卡宾（NHCs）已成为用于各种转化的强大有机催化剂，并继续得到广泛应用。在过去十年中，由NHCs催化的多米诺反应取得了显著进展，因为不同的活化模式可以在一个过程中成功结合。这些多米诺序列最吸引人的特点包括催化剂和底物易于获得、操作程序简单，以及在温和反应条件下以优异的立体控制水平快速组装复杂分子骨架。本综述通过关注反应范围、局限性和机理，并密切关注反应底物的特点，涵盖了NHCs催化多米诺反应的进展。
