利用持久自由基效应合成桥联二酮哌嗪和双环霉素的形式合成。
Synthesis of bridged diketopiperazines by using the persistent radical effect and a formal synthesis of bicyclomycin.
机构信息
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo náměstí 2, 16610 Prague (Czech Republic).
Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030/8, 12843 Prague (Czech Republic).
出版信息
Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12153-7. doi: 10.1002/anie.201504883. Epub 2015 Aug 25.
A conceptually new and unified approach to diverse bridged diketopiperazines (DKPs) with widely variable ring sizes was developed by taking advantage of the persistent radical effect. This method enables synthesis of the core structures of bridged DKP alkaloids and was applied to a formal synthesis of the antibiotic bicyclomycin.
发展了一种概念全新且统一的方法，可以通过利用持久自由基效应来合成具有广泛变化的环大小的各种桥环二酮哌嗪（DKP）。该方法能够合成桥环 DKP 生物碱的核心结构，并应用于抗生素双环霉素的全合成。
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