González-Barón S, Dawid-Milner M S, Lara J P, Clavijo E, Aguirre J A
Departamento de Fisiología, Facultad de Medicina, Málaga, España.
Rev Esp Fisiol. 1989;45 Suppl:191-6.
The modifications of larynx resistance changing bronchial tone were studied in cats. Changes on bronchial tone were evoked by intravenous administration of Carbachol (10 micrograms/kg) as bronchoconstrictor, and by Fenoterol (10 micrograms/kg) and Isoprenaline (0.1 mg/kg) as bronchodilators. The effects of Carbachol administration after these drugs were also studied. Larynx resistance was measured by the subglottic pressure value using the in situ isolated glottis technique. Subglottic pressure increases after Carbachol administration (p less than 0.001) and decreases after Fenoterol (p less than 0.02) and Isoprenaline (p less than 0.01). When Carbachol was administered after the bronchodilators subglottic pressure values were similar to those observed in control situations. A high positive correlation between changes of subglottic pressure and total lung resistance (p less than 0.01) was also observed. These results could suggest that glottis contraction was reflexively modified by bronchial tone.
在猫身上研究了喉阻力变化对支气管张力的影响。静脉注射卡巴胆碱(10微克/千克)作为支气管收缩剂,注射非诺特罗(10微克/千克)和异丙肾上腺素(0.1毫克/千克)作为支气管扩张剂,从而引起支气管张力的变化。还研究了在这些药物之后注射卡巴胆碱的效果。采用原位分离声门技术,通过声门下压力值来测量喉阻力。注射卡巴胆碱后声门下压力升高(p<0.001),注射非诺特罗后降低(p<0.02),注射异丙肾上腺素后降低(p<0.01)。在支气管扩张剂之后注射卡巴胆碱时,声门下压力值与对照情况下观察到的值相似。还观察到声门下压力变化与总肺阻力之间存在高度正相关(p<0.01)。这些结果可能表明,声门收缩会因支气管张力而发生反射性改变。