Alfonso M, Marcó J, Balvis I A, Venta R
Departamento de Fisiología, Facultad de Bioloía, Universidad de Santiago, Santiago de Compostela.
Rev Esp Fisiol. 1989;45 Suppl:79-86.
The effect of ethanol administered at 18.00 h. of diestrus 2 on prolactin secretion has been studied in rats. Serum levels and pituitary content of prolactin were measured at 30, 60, 90 and 120 min. after administration of different doses of ethanol (0.5, 2 and 4 g/kg). Moreover, the variation of the prolactin release was determined at different hours of the rat estrous cycle, after administration of a single dose of ethanol (2 g/kg) at 18.00 h of diestrus. 2. Serum prolactin levels were significantly elevated after the preovulatory administration of ethanol with all the doses tested. The hyperprolactinemia appeared 60 min after ethanol treatment and the high prolactin levels were maintained during all the estrous cycles, especially in the proestrus day. The normal levels were re-established the 5th day after treatment. The ethanol produced a byphasic effect on pituitary prolactin content. During the first post-treatment hours, the pituitary prolactin concentration decreased with respect to the control group, but 24 hours after treatment, these values were increased and the normal concentration was restored 36 hours after treatment.
研究了在动情周期第2阶段的18:00给予乙醇对大鼠催乳素分泌的影响。在给予不同剂量乙醇（0.5、2和4 g/kg）后的30、60、90和120分钟测量血清催乳素水平和垂体催乳素含量。此外，在动情周期的不同时间，于动情周期第2阶段的18:00给予单剂量乙醇（2 g/kg）后，测定催乳素释放的变化。2. 在排卵前给予所有测试剂量的乙醇后，血清催乳素水平显著升高。乙醇处理后60分钟出现高催乳素血症，并且在整个动情周期中催乳素水平都维持在高位，尤其是在动情前期。治疗后第5天恢复正常水平。乙醇对垂体催乳素含量产生双相作用。在治疗后的最初几个小时内，垂体催乳素浓度相对于对照组降低，但治疗后24小时，这些值升高，治疗后36小时恢复正常浓度。
