Giannos Steven A
University of Texas, Medical Branch, 700 University Blvd., Galveston, TX 77551, USA.
Ther Deliv. 2015;6(9):1033-41. doi: 10.4155/tde.15.62. Epub 2015 Sep 30.
Transdermal systems have become an accepted means of drug delivery, offering clinical benefits over other dosage forms. Although transdermal delivery has been very successful as a controlled release technology platform, there are a number of challenges that prevent this delivery route from achieving its fullest commercial potential. Additionally, beginning in 1997, transdermal drug delivery companies aligned with life science industries to deliver large molecules, peptides and proteins through the skin, which is difficult due to the skin barrier properties. A number of methods and technologies have been conceived to overcome the skin barrier. Among these are mechanical, chemical and thermal permeation enhancement techniques. These methods are briefly discussed as well as future directions for transdermal therapies.
透皮给药系统已成为一种被认可的药物递送方式，与其他剂型相比具有临床优势。尽管透皮给药作为一种控释技术平台已经非常成功，但仍存在一些挑战，阻碍了这种给药途径充分发挥其商业潜力。此外，从1997年开始，透皮给药公司与生命科学行业合作，试图通过皮肤递送大分子、肽和蛋白质，但由于皮肤的屏障特性，这一过程颇具难度。人们已经设想了许多方法和技术来克服皮肤屏障。其中包括机械、化学和热渗透增强技术。本文将简要讨论这些方法以及透皮治疗的未来发展方向。
