多巴胺对循环及心肌氧供应的影响。
Dopamine effects on circulation and myocardial oxygen supply.
作者信息
Brückner J B, Hess W, Schmidt D, Schneider E, Schweichel E
出版信息
Proc R Soc Med. 1977;70 Suppl 2(Suppl 2):43-7. doi: 10.1177/00359157770700S208.
We measured the action of dopamine given intravenously at dosage ranging from 2.5 to 320 micrograms/kg per min in closed chest anaesthetized dogs. Dopamine produced a dose-dependent increase in heart rate, cardiac index, mean arterial pressure, total peripheral resistance, pulmonary artery pressure, left ventricular end diastolic pressure, coronary flow and myocardial oxygen consumption. At dopamine dosage of 80-320 micrograms/kg per min, the coronary vascular resistance, the stroke volume index, the efficiency of heart work and the central venous pressure are all decreased. The maximum effect of dopamine on the circulation was seen at a dose between 40 and 80 micrograms/kg per min.
我们在开胸麻醉犬身上测量了静脉注射多巴胺的作用，剂量范围为每分钟2.5至320微克/千克。多巴胺使心率、心脏指数、平均动脉压、总外周阻力、肺动脉压、左心室舒张末期压力、冠状动脉血流量和心肌耗氧量呈剂量依赖性增加。在多巴胺剂量为每分钟80 - 320微克/千克时，冠状动脉血管阻力、每搏量指数、心脏作功效率和中心静脉压均降低。多巴胺对循环系统的最大作用出现在剂量为每分钟40至80微克/千克之间。
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