Santoro Orlando, Lazreg Faïma, Minenkov Yury, Cavallo Luigi, Cazin Catherine S J
EaStCHEM School of Chemistry, University of St Andrews, St Andrews, KY16 9ST, UK.
Dalton Trans. 2015 Nov 7;44(41):18138-44. doi: 10.1039/c5dt03506f. Epub 2015 Sep 30.
The N-methylation of amines using CO2 and PhSiH3 as source of CH3 was efficiently performed using a N-heterocyclic carbene copper(i) complex. The methodology was found compatible with aromatic and aliphatic primary and secondary amines. Synthetic and computational studies have been carried out to support the proposed reaction mechanism for this transformation.
使用N-杂环卡宾铜（I）配合物，能高效地实现以二氧化碳和苯基硅烷作为甲基来源对胺进行N-甲基化反应。该方法被发现与芳香族和脂肪族的伯胺和仲胺都兼容。已开展合成研究和计算研究以支持这种转化反应的拟议反应机理。
