Gomes Debora C, Valadares Ana L R, Amaral Eliana, Ferreira Néville de Oliveira, Pinto-Neto Aarão M, Baccaro Luiz Francisco, Costa-Paiva Lúcia
Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Department of Climacteric, School of Medicine of José do Rosário Vellano University (UNIFENAS), Belo Horizonte, Minas Gerais, Brazil.
Arch Osteoporos. 2015;10:33. doi: 10.1007/s11657-015-0238-z. Epub 2015 Sep 29.
A cross-sectional study was conducted with the purpose of evaluating bone mineral density in HIV seropositive and seronegative climacteric women. HIV infection was negatively associated with bone mineral density in the lumbar spine
To assess bone mineral density (BMD) and its associated factors in HIV seropositive and seronegative climacteric women
A cross-sectional study with 537 women (273 HIV seropositive and 264 HIV seronegative) aged between 40 and 60 years old receiving follow-up care at two hospitals in Brazil. A questionnaire on clinical and sociodemographic characteristics was completed. Laboratory tests were performed, and BMD was measured at the lumbar spine and hip. Statistical analysis was carried out by Yates and Pearson chi-squared tests, Mann-Whitney test, and multiple linear regression.
The mean age was 47.7 years in HIV-seropositive women, and 75 % had nadir CD4 above 200, and 77.8 % had viral load below the detection limit. The mean age in the HIV-seronegative women was 49.8 years. The prevalence of low spinal BMD was 14.6 % in the HIV-seropositive and 4.6 % in the HIV-seronegative women (p < 0.01). The prevalence of low BMD at the femoral neck was 5.6 % in HIV-seropositive and 3.3 % in the HIV-seronegative women (p = 0.38). Multiple analyses showed that the factors associated with lower BMD at the spine were being postmenopausal and being HIV-seropositive. Being overweight was associated with a higher BMD. At the femoral neck, factors associated with lower BMD were being postmenopausal and being white. Being overweight and having a greater number of pregnancies were associated with higher BMD CONCLUSIONS: HIV-seropositive women on long-term antiretroviral treatment and in good immunological conditions exhibited low BMD in the spine (L1-L4). However, BMD in the femoral neck was similar to non-infected women.
进行了一项横断面研究，目的是评估HIV血清阳性和血清阴性的更年期女性的骨矿物质密度。HIV感染与腰椎骨矿物质密度呈负相关。
评估HIV血清阳性和血清阴性的更年期女性的骨矿物质密度（BMD）及其相关因素。
对巴西两家医院接受随访的537名年龄在40至60岁之间的女性进行了横断面研究（273名HIV血清阳性和264名HIV血清阴性）。完成了一份关于临床和社会人口学特征的问卷。进行了实验室检查，并测量了腰椎和髋部的骨矿物质密度。通过Yates和Pearson卡方检验、Mann-Whitney检验和多元线性回归进行统计分析。
HIV血清阳性女性的平均年龄为47.7岁，75%的患者最低CD4高于200，77.8%的患者病毒载量低于检测限。HIV血清阴性女性的平均年龄为49.8岁。HIV血清阳性女性中低脊柱骨密度的患病率为14.6%，HIV血清阴性女性中为4.6%（p<0.01）。HIV血清阳性女性中股骨颈低骨密度的患病率为5.6%，HIV血清阴性女性中为3.3%（p=0.38）。多元分析表明，与脊柱骨密度降低相关的因素是绝经后和HIV血清阳性。超重与较高的骨密度相关。在股骨颈，与骨密度降低相关的因素是绝经后和白人。超重和怀孕次数较多与较高的骨密度相关。结论：长期接受抗逆转录病毒治疗且免疫状况良好的HIV血清阳性女性脊柱（L1-L4）骨密度较低。然而，股骨颈的骨密度与未感染女性相似。
