Schörner Mario, Beyer Sebastian Reinhardt, Southall June, Cogdell Richard J, Köhler Jürgen
Experimental Physics IV and Bayreuth Institute for Macromolecular Research (BIMF), University of Bayreuth , 95447 Bayreuth, Germany.
Institute of Molecular, Cell & Systems Biology, College of Medical Veterinary and Life Sciences, University of Glasgow , Glasgow G12 8QQ, United Kingdom.
J Phys Chem B. 2015 Nov 5;119(44):13964-70. doi: 10.1021/acs.jpcb.5b07494. Epub 2015 Oct 14.
Proteins are supramolecular machines that carry out a wide range of different functions, many of which require flexibility. Up until now spontaneous conformational fluctuations of proteins have always been assumed to reflect a stochastic random process. However, if changing between different conformational states was random, then it would be difficult to understand how conformational control of protein function could have evolved. Here we demonstrate that a single protein can show conformational memory. This is exactly the process that can facilitate the evolution of control of switching between two conformational states that can then be used to regulate protein function.
蛋白质是执行多种不同功能的超分子机器，其中许多功能都需要灵活性。到目前为止，人们一直认为蛋白质的自发构象波动反映的是一个随机过程。然而，如果在不同构象状态之间的转变是随机的，那么就很难理解蛋白质功能的构象控制是如何进化的。在这里，我们证明了单个蛋白质可以表现出构象记忆。这正是一个能够促进两种构象状态之间转换控制进化的过程，而这种转换随后可用于调节蛋白质功能。
