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三氟化硼乙醚络合物催化的4-芳基-3-苯基苯并吡喃、前选择性雌激素受体调节剂及其表征

BF3·Et2O Catalysed 4-Aryl-3-phenyl-benzopyrones, Pro-SERMs, and Their Characterization.

作者信息

Srivastava Ambika, Singh Pooja, Kumar Rajesh

机构信息

Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University, Varanasi 221005, India.

出版信息

Adv Pharmacol Sci. 2015;2015:527159. doi: 10.1155/2015/527159. Epub 2015 Sep 1.

DOI:10.1155/2015/527159
PMID:26421007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4569759/
Abstract

We have synthesized the novel 4-(4-hydroxy-benzyl)-3-phenyl-chromen-2-one which is a precursor of SERMs with a smaller number of steps and good yield. Two methodologies for the synthesis have been worked out. Anhydrous BF3·Et2O catalyzed reaction was found to be selective for product formation while anhydrous AlCl3, FeCl3, and SnCl4 catalyzed ones were nonselective.

摘要

我们已经合成了新型的4-(4-羟基苄基)-3-苯基色原酮-2-酮，它是一种合成步骤较少且产率良好的选择性雌激素受体调节剂（SERM）前体。已经研究出两种合成方法。发现无水三氟化硼·乙醚催化反应对产物形成具有选择性，而无水三氯化铝、三氯化铁和四氯化锡催化的反应则无选择性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/4569759/a3c881d013dd/APS2015-527159.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/4569759/4c3ed184eff0/APS2015-527159.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/4569759/34a65bf2f71a/APS2015-527159.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/4569759/2065834587c8/APS2015-527159.sch.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/4569759/77bb08164cec/APS2015-527159.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/4569759/a3c881d013dd/APS2015-527159.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/4569759/4c3ed184eff0/APS2015-527159.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/4569759/34a65bf2f71a/APS2015-527159.sch.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/4569759/2065834587c8/APS2015-527159.sch.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/4569759/77bb08164cec/APS2015-527159.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ac2/4569759/a3c881d013dd/APS2015-527159.003.jpg

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