Kemal Y, Teker F, Demirag G, Yucel I
Department of Medical Oncology, Faculty of Medicine, Ondokuz Mayis University, Samsun 55139, Turkey.
Department of Medical Oncology, Faculty of Medicine, 19 Mayis University, Samsun 55139, Turkey.
Exp Oncol. 2015 Sep;37(3):223-6.
Primary testicular lymphoma (PTL) is an uncommon and aggressive form of extranodal non-Hodgkin's lymphoma (NHL). We aimed to analyse the clinicopathological characteristics and outcomes of our PTL cases.
A review was made of the medical records of 339 NHL patients who were treated in the Medical Oncology Department between January 2005 and December 2013.
8 PTL patients were identified from the 339 NHL patients. The average age of the patients was 67.7 ± 7.9 years (range 53-79 years). The mean follow-up time was 24.8 months (range 7-98 months). Inguinal orchiectomy was performed as a diagnostic and initial therapy and all the patients underwent 4-6 cycles of chemoimmunotherapy consisting of cyclophosphamide, doxorubicin, vincristine and prednisone plus rituximab. 4 of 8 patients received intrathecal prophylactic chemotherapy and 6 of 8 patients continued contralateral testis irradiation. Relapse occured in only 1 patient in central nervous system after 6 months who had not received intrathecal prophylaxis. No contralateral testis relapse was observed.
Primary testicular NHL is an uncommon entity and we evaluated 8 patients; with one relapse in central nervous system and no relapse in the contralateral testis.
原发性睾丸淋巴瘤（PTL）是一种罕见的、侵袭性的结外非霍奇金淋巴瘤（NHL）。我们旨在分析我们所诊治的PTL病例的临床病理特征及预后。
回顾性分析2005年1月至2013年12月在肿瘤内科接受治疗的339例NHL患者的病历资料。
在339例NHL患者中确诊8例PTL患者。患者的平均年龄为67.7±7.9岁（范围53 - 79岁）。平均随访时间为24.8个月（范围7 - 98个月）。行腹股沟睾丸切除术作为诊断及初始治疗，所有患者均接受了4 - 6周期的化疗免疫治疗，方案包括环磷酰胺、阿霉素、长春新碱、泼尼松加利妥昔单抗。8例患者中有4例接受了鞘内预防性化疗，8例患者中有6例继续接受对侧睾丸放疗。仅1例未接受鞘内预防性化疗的患者在6个月后出现中枢神经系统复发。未观察到对侧睾丸复发。
原发性睾丸NHL是一种罕见的疾病，我们评估了8例患者；1例出现中枢神经系统复发，对侧睾丸未复发。
