CA 15-3对局部晚期乳腺癌复发早期检测的临床价值

[Clinical value of CA 15-3 for early detection of relapse in locally advanced breast cancer].

作者信息

Konan Stéphane, Goussot Vincent, Desmoulins Isabelle, Lorgis Véronique, Coutant Charles, Fumoleau Pierre, Beltjens Françoise, Dalban Cécile, Lizard Sarab, Riedinger Jean-Marc

机构信息

Centre Georges-François-Leclerc, département de biologie et pathologie des tumeurs, 1, rue de Pr.-Marion, 21079 Dijon cedex, France.

Centre Georges-François-Leclerc, département d'oncologie médicale, 1, rue de Pr.-Marion, 21079 Dijon cedex, France.

出版信息

Bull Cancer. 2015 Oct;102(10):834-44. doi: 10.1016/j.bulcan.2015.07.011. Epub 2015 Sep 28.

DOI:10.1016/j.bulcan.2015.07.011

PMID:26422277

Abstract

This retrospective study evaluates the interest of CA 15-3 measurement for early detection of breast cancer recurrences. Among 804 patients with invasive breast cancer we selected 117 patients without recurrence (WR) for 5 years or more, 33 with a local recurrence (LR) and 149 with at least one distant metastasis (DM). The sensitivity of CA 15-3 depends on the type of recurrence ([LR] or [DM]), the localization of unique DM, the presence and the number of metastatic sites, on hormonal receptor status and tumor subtypes. The number of metastatic sites and hormonal receptor status are independent predictive criteria of an elevation of CA 15-3. The analysis of ROC curve in order to separate patients with DM and patients WR shows an AUC of 0.87 (p<0.0001). The optimal discriminative threshold is 26 kU/L. In conclusion, these data confirm that CA 15-3 increase depends on the kind of evolution and on initial tumor's hormonal status.

摘要

这项回顾性研究评估了CA 15-3检测对乳腺癌复发早期诊断的价值。在804例浸润性乳腺癌患者中，我们选取了117例5年及以上无复发（WR）的患者、33例局部复发（LR）的患者以及149例至少有一处远处转移（DM）的患者。CA 15-3的敏感性取决于复发类型（[LR]或[DM]）、单一远处转移的部位、转移部位的数量和存在情况、激素受体状态以及肿瘤亚型。转移部位的数量和激素受体状态是CA 15-3升高的独立预测指标。为区分远处转移患者和无复发患者而进行的ROC曲线分析显示，曲线下面积（AUC）为0.87（p<0.0001）。最佳鉴别阈值为26 kU/L。总之，这些数据证实，CA 15-3升高取决于病情发展类型和初始肿瘤的激素状态。