结节病与静脉血栓栓塞风险：一项系统评价和荟萃分析。
Sarcoidosis and risk of venous thromboembolism: A systematic review and meta-analysis.
作者信息
Ungprasert Patompong, Srivali Narat, Wijarnpreecha Karn, Thongprayoon Charat
机构信息
Mayo Clinic, Rochester, MN.
出版信息
Sarcoidosis Vasc Diffuse Lung Dis. 2015 Sep 14;32(3):182-7.
BACKGROUND
Several chronic inflammatory disorders, such as rheumatoid arthritis, inflammatory myositis and systemic lupus erythematosus, have been linked to an increased risk of venous thromboembolism (VTE). However, the data on sarcoidosis is unclear.
OBJECTIVES
To evaluate the risk of VTE among patients with sarcoidosis.
METHODS
We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio or standardized incidence ratio comparing risk of VTE in patients with sarcoidosis versus non-sarcoidosis participants. Estimated effects were extracted from each study and were pooled together using the random-effect, generic inverse variance method of DerSimonian and Laird.
RESULT
Out of 772 potentially relevant articles, three eligible studies were identified and included in the data analysis. The pooled risk ratio of VTE in patients with sarcoidosis was 1.42 (95% CI, 1.12-1.79). The statistical heterogeneity of this study was moderate with an I2 of 72%.
CONCLUSION
Our study demonstrated a statistically significant increased VTE risk among patients with sarcoidosis.
背景
几种慢性炎症性疾病，如类风湿性关节炎、炎性肌病和系统性红斑狼疮，都与静脉血栓栓塞（VTE）风险增加有关。然而，关于结节病的数据尚不清楚。
目的
评估结节病患者发生VTE的风险。
方法
我们对观察性研究进行了系统评价和荟萃分析，这些研究报告了比较结节病患者与非结节病参与者VTE风险的比值比、相对风险、风险比或标准化发病率比。从每项研究中提取估计效应，并使用DerSimonian和Laird的随机效应、通用逆方差方法进行汇总。
结果
在772篇潜在相关文章中，确定了三项符合条件的研究并纳入数据分析。结节病患者VTE的合并风险比为1.42（95%CI，1.12 - 1.79）。本研究的统计异质性为中度，I²为72%。
结论
我们的研究表明，结节病患者的VTE风险在统计学上显著增加。
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