Ruaro Barbara, Confalonieri Paola, Santagiuliana Mario, Wade Barbara, Baratella Elisa, Kodric Metka, Berria Maria, Jaber Mohamad, Torregiani Chiara, Bruni Cosimo, Confalonieri Marco, Salton Francesco
Department of Pulmonology, University Hospital of Cattinara, 34127 Trieste, Italy.
AOU City of Health and Science of Turin, Department of Science of Public Health and Pediatrics, University of Torino, 10126 Torino, Italy.
J Clin Med. 2021 Jun 2;10(11):2462. doi: 10.3390/jcm10112462.
Some studies with inconclusive results have reported a link between sarcoidosis and an increased risk of pulmonary embolism (PE). This study aimed at assessing a possible correlation between potential risk factors and PE in sarcoidosis patients.
A total of 256 sarcoidosis patients (84 males and 172 females; mean age at diagnosis 49 ± 13) were enrolled after giving written informed consent. Clinical evaluations, laboratory and radiology tests were performed to evaluate the presence of pulmonary embolism.
Fifteen sarcoidosis patients with PE (4 males and 11 females; mean age at diagnosis 50 ± 11), diagnosed by lung scintigraphy and 241 sarcoidosis patients without PE (80 males and 161 females; mean age at diagnosis 47 ± 13), were observed. There was a statistically significant increase of the presence of antiphospholipid antibodies in the sarcoidosis group with pulmonary embolism. There was no statistically significant difference between the two groups as to smoking habit, obesity or hereditary thrombophilia frequency ( > 0.05, respectively).
This study demonstrates a significant correlation between the presence of antiphospholipid antibody positivity and the pulmonary embolism events in our sarcoidosis patients. Furthermore, we propose screening for these antibodies and monitoring, aimed at timely treatment.
一些结果尚无定论的研究报告称结节病与肺栓塞（PE）风险增加之间存在关联。本研究旨在评估结节病患者潜在风险因素与肺栓塞之间的可能相关性。
在获得书面知情同意后，共纳入256例结节病患者（男性84例，女性172例；诊断时平均年龄49±13岁）。进行临床评估、实验室检查和影像学检查以评估肺栓塞的存在情况。
观察到15例经肺闪烁显像诊断为肺栓塞的结节病患者（男性4例，女性11例；诊断时平均年龄50±11岁）和241例无肺栓塞的结节病患者（男性80例，女性161例；诊断时平均年龄47±13岁）。肺栓塞结节病组中抗磷脂抗体的存在有统计学意义的增加。两组在吸烟习惯、肥胖或遗传性血栓形成倾向频率方面无统计学显著差异（分别>0.05）。
本研究表明抗磷脂抗体阳性与我们的结节病患者中的肺栓塞事件之间存在显著相关性。此外，我们建议筛查这些抗体并进行监测，以便及时治疗。
