针对重度抑郁症和共病焦虑障碍的特定障碍治疗与跨诊断治疗、临床医生指导治疗与自我指导治疗的比较：一项随机对照试验。
Disorder-specific versus transdiagnostic and clinician-guided versus self-guided treatment for major depressive disorder and comorbid anxiety disorders: A randomized controlled trial.
机构信息
eCentreClinic, Department of Psychology, Macquarie University, Sydney, Australia.
eCentreClinic, Department of Psychology, Macquarie University, Sydney, Australia.
出版信息
J Anxiety Disord. 2015 Oct;35:88-102. doi: 10.1016/j.janxdis.2015.08.002. Epub 2015 Aug 31.
Disorder-specific cognitive behavior therapy (DS-CBT) is effective at treating major depressive disorder (MDD) while transdiagnostic CBT (TD-CBT) addresses both principal and comorbid disorders by targeting underlying and common symptoms. The relative benefits of these two models of therapy have not been determined. Participants with MDD (n=290) were randomly allocated to receive an internet delivered TD-CBT or DS-CBT intervention delivered in either clinician-guided (CG-CBT) or self-guided (SG-CBT) formats. Large reductions in symptoms of MDD (Cohen's d≥1.44; avg. reduction≥45%) and moderate-to-large reductions in symptoms of comorbid generalised anxiety disorder (Cohen's d≥1.08; avg. reduction≥43%), social anxiety disorder (Cohen's d≥0.65; avg. reduction≥29%) and panic disorder (Cohen's d≥0.45; avg. reduction≥31%) were found. No marked or consistent differences were observed across the four conditions, highlighting the efficacy of different forms of CBT at treating MDD and comorbid disorders.
特定障碍认知行为疗法（DS-CBT）在治疗重度抑郁症（MDD）方面非常有效，而共病认知行为疗法（TD-CBT）通过针对潜在和共同的症状来治疗主要障碍和共病障碍。这两种治疗模式的相对益处尚未确定。将 290 名患有 MDD 的参与者随机分配接受互联网提供的 TD-CBT 或在临床医生指导（CG-CBT）或自我指导（SG-CBT）格式下提供的 DS-CBT 干预。MDD 的症状大幅减轻（Cohen's d≥1.44；平均减轻≥45%），共病广泛性焦虑症（Cohen's d≥1.08；平均减轻≥43%）、社交焦虑症（Cohen's d≥0.65；平均减轻≥29%）和恐慌症（Cohen's d≥0.45；平均减轻≥31%）的症状也得到了中度至大幅度的减轻。在这四种情况下没有观察到明显或一致的差异，这突出了不同形式的 CBT 在治疗 MDD 和共病障碍方面的疗效。
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