使用可回收的高价碘试剂通过无金属氧化交叉偶联合成N-吡咯基唑类化合物。

Clean Synthesis of N-Pyrrolyl Azoles by Metal-Free Oxidative Cross-Coupling Using Recyclable Hypervalent Iodine Reagent.

作者信息

Morimoto Koji, Ogawa Ryosuke, Koseki Daichi, Takahashi Yusuke, Dohi Toshifumi, Kita Yasuyuki

机构信息

College of Pharmaceutical Sciences, Ritsumeikan University.

出版信息

Chem Pharm Bull (Tokyo). 2015;63(10):819-24. doi: 10.1248/cpb.c15-00469.

DOI:10.1248/cpb.c15-00469

PMID:26423039

Abstract

The facile and clean oxidative coupling reaction of pyrroles with azoles has been achieved using the recyclable hypervalent iodine(III) reagents having adamantane structures. These iodine(III) reagents could be recovered from the reaction mixtures by a simple solid-liquid separation, i.e., filtration, for reuse.

摘要

使用具有金刚烷结构的可回收高价碘（III）试剂，已实现吡咯与唑类的简便且无污染的氧化偶联反应。这些碘（III）试剂可通过简单的固液分离（即过滤）从反应混合物中回收，以供再利用。