碘催化吲哚与唑类的氧化交叉偶联反应：N-连接的2-(唑-1-基)吲哚衍生物的区域选择性合成

Iodine-catalyzed oxidative cross-coupling of indoles and azoles: regioselective synthesis of N-linked 2-(azol-1-yl)indole derivatives.

作者信息

Beukeaw Danupat, Udomsasporn Kwanchanok, Yotphan Sirilata

机构信息

Center for Catalysis and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.

出版信息

J Org Chem. 2015 Apr 3;80(7):3447-54. doi: 10.1021/jo502933e. Epub 2015 Mar 20.

DOI:10.1021/jo502933e

PMID:25791508

Abstract

A highly efficient iodine-catalyzed regioselective oxidative cross-coupling of an indole C-H bond and azole N-H bond is described. This metal-free reaction can be easily carried out at room temperature under mild and environmentally friendly conditions and provides a series of N-linked 2-(azol-1-yl)indole derivatives in moderate to excellence yields.

摘要

描述了一种高效的碘催化吲哚C-H键与唑N-H键的区域选择性氧化交叉偶联反应。这种无金属反应可以在室温下在温和且环境友好的条件下轻松进行，并以中等至优异的产率提供一系列N-连接的2-（唑-1-基）吲哚衍生物。