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便秘的结肠切除术:基于1998 - 2011年美国全国住院患者样本的时间趋势及影响

Colectomy for constipation: time trends and impact based on the US Nationwide Inpatient Sample, 1998-2011.

作者信息

Dudekula A, Huftless S, Bielefeldt K

机构信息

Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Department of Medicine, Division of Gastroenterology & Hepatology, Johns Hopkins University, Baltimore, MD, USA.

出版信息

Aliment Pharmacol Ther. 2015 Dec;42(11-12):1281-93. doi: 10.1111/apt.13415. Epub 2015 Oct 1.

Abstract

BACKGROUND

Current guidelines include subtotal colectomy as treatment for refractory slow transit constipation.

AIM

To use the US Nationwide Inpatient Sample (NIS) (1998-2011) and longitudinal data from the State Inpatient Database (2005-2011), comparable to NIS, to examine colectomy rates, in-hospital morbidity and emergency department (ED) visits or readmissions among patients treated for constipation.

METHODS

Colectomies for any reason were identified based on the primary procedural code (ICD-9-CM 45.8x). Index hospitalisations were defined by the primary diagnosis of constipation (ICD-9-CM 564.x) associated with the primary procedural code for colectomy (ICD-9-CM45.8x) after exclusion of other diseases associated with colectomy. Demographic variables, comorbidities, complications and adverse events during the hospitalisation were captured, and ED visits and admissions were recorded for periods before and after colectomy.

RESULTS

Nationally, colectomies for constipation rose from 104 procedures in 1998 (1.2% of annual colectomies) to 311 in 2011 (2.4% of annual colectomies). While there were no perioperative deaths, perioperative complications occurred in 42.7% of patients during the index hospitalisation. Longitudinal data were analysed for 181 patients, with similar perioperative complications and a readmission rate of 28.9% within the first 30 days after the index hospitalisation. Resource utilisation was tracked for a median time of 630 (0-2386) before and 463 (0-2204) days after colectomy with unchanged ED visits (median: 2 vs. 2, P = 0.21), but increased hospitalisations (median: 1 vs. 2, P = 0.003).

CONCLUSIONS

Colectomy rates for constipation are rising, are associated with significant morbidity and do not decrease resource utilisation, raising questions about the true benefit of surgery for slow transit constipation.

摘要

背景

当前指南将次全结肠切除术作为难治性慢传输型便秘的治疗方法。

目的

利用美国全国住院患者样本(NIS,1998 - 2011年)以及与NIS可比的州住院患者数据库(2005 - 2011年)的纵向数据,研究接受便秘治疗患者的结肠切除率、住院期间发病率以及急诊科就诊或再入院情况。

方法

根据主要手术编码(ICD - 9 - CM 45.8x)确定因任何原因进行的结肠切除术。排除与结肠切除术相关的其他疾病后,索引住院定义为由便秘的主要诊断(ICD - 9 - CM 564.x)与结肠切除术的主要手术编码(ICD - 9 - CM 45.8x)相关联。记录住院期间的人口统计学变量、合并症、并发症和不良事件,并记录结肠切除术前和术后期间的急诊科就诊和入院情况。

结果

在全国范围内,因便秘进行的结肠切除术从1998年的104例手术(占年度结肠切除术的1.2%)增至2011年的311例(占年度结肠切除术的2.4%)。虽然围手术期无死亡病例,但在索引住院期间,42.7%的患者发生了围手术期并发症。对181例患者的纵向数据进行了分析,围手术期并发症相似,索引住院后前30天内的再入院率为28.9%。跟踪结肠切除术前和术后的资源利用情况,术前中位时间为630(0 - 2386)天,术后为463(0 - 2204)天,急诊科就诊情况未变(中位数:2次对2次,P = 0.21),但住院次数增加(中位数:1次对2次,P = 0.003)。

结论

便秘的结肠切除率在上升,与显著的发病率相关,且并未降低资源利用,这引发了关于手术治疗慢传输型便秘真正益处的疑问。

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