淋巴细胞性脉络丛脑膜炎病毒和皮钦德病毒对巨噬细胞激活的差异性抑制由Z蛋白N端结构域介导。
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain.
作者信息
Xing Junji, Chai Zheng, Ly Hinh, Liang Yuying
机构信息
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, Minnesota, USA.
Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Twin Cities, Minnesota, USA
出版信息
J Virol. 2015 Dec;89(24):12513-7. doi: 10.1128/JVI.01674-15. Epub 2015 Sep 30.
Abstract
Several arenavirus pathogens, such as Lassa and Junin viruses, inhibit macrophage activation, the molecular mechanism of which is unclear. We show that lymphocytic choriomeningitis virus (LCMV) can also inhibit macrophage activation, in contrast to Pichinde and Tacaribe viruses, which are not known to naturally cause human diseases. Using a recombinant Pichinde virus system, we show that the LCMV Z N-terminal domain (NTD) mediates the inhibition of macrophage activation and immune functions.
摘要
几种沙粒病毒病原体，如拉沙病毒和胡宁病毒，会抑制巨噬细胞激活，其分子机制尚不清楚。我们发现淋巴细胞性脉络丛脑膜炎病毒（LCMV）也能抑制巨噬细胞激活，这与皮钦德病毒和塔卡里伯病毒不同，后者并非已知的自然导致人类疾病的病毒。利用重组皮钦德病毒系统，我们发现LCMV的Z蛋白N端结构域（NTD）介导了对巨噬细胞激活和免疫功能的抑制。
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