Chang Stanley, Hur Soo, Britton Robert
Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, V5A 1S6 (Canada).
Chemistry. 2015 Nov 9;21(46):16646-53. doi: 10.1002/chem.201502754. Epub 2015 Oct 1.
The total synthesis of the marine fungus-derived natural product ascospiroketal is described. This concise synthesis relies on a unique Ag(I) -promoted tandem cascade cyclization that provides direct access to the correctly configured tricyclic core of the natural product from a linear precursor. The synthesis of candidate stereostructures of ascospiroketal A allowed for the confident assignment of both the relative and absolute stereochemistry of this unusual octaketide.
本文描述了海洋真菌来源的天然产物ascospiroketal的全合成。这种简洁的合成方法依赖于一种独特的银（I）促进的串联级联环化反应，该反应能够从线性前体直接获得具有正确构型的天然产物三环核心。ascospiroketal A候选立体结构的合成使得能够确定这种不寻常的八酮类化合物的相对和绝对立体化学。
