Winkler Ethan A, Yue John K, Birk Harjus, Robinson Caitlin K, Manley Geoffrey T, Dhall Sanjay S, Tarapore Phiroz E
Department of Neurological Surgery, University of California, San Francisco; and Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, California.
Neurosurg Focus. 2015 Oct;39(4):E2. doi: 10.3171/2015.7.FOCUS15270.
OBJECT Traumatic fractures of the thoracolumbar spine are common injuries, accounting for approximately 90% of all spinal trauma. Lumbar spine trauma in the elderly is a growing public health problem with relatively little evidence to guide clinical management. The authors sought to characterize the complications, morbidity, and mortality associated with surgical and nonsurgical management in elderly patients with traumatic fractures of the lumbar spine. METHODS Using the National Sample Program of the National Trauma Data Bank, the authors performed a retrospective analysis of patients ≥ 55 years of age who had traumatic fracture to the lumbar spine. This group was divided into middle-aged (55-69 years) and elderly (≥ 70 years) cohorts. Cohorts were subdivided into nonoperative, vertebroplasty or kyphoplasty, noninstrumented surgery, and instrumented surgery. Univariate and multivariable analyses were used to characterize and identify predictors of medical and surgical complications, mortality, hospital length of stay, ICU length of stay, number of days on ventilator, and hospital discharge in each subgroup. Adjusted odds ratios, mean differences, and associated 95% CIs were reported. Statistical significance was assessed at p < 0.05, and the Bonferroni correction for multiple comparisons was applied for each outcome analysis. RESULTS Between 2003 and 2012, 22,835 people met the inclusion criteria, which represents 94,103 incidents nationally. Analyses revealed a similar medical and surgical complication profile between age groups. The most prevalent medical complications were pneumonia (7.0%), acute respiratory distress syndrome (3.6%), and deep venous thrombosis (3%). Surgical site infections occurred in 6.3% of cases. Instrumented surgery was associated with the highest odds of each complication (p < 0.001). The inpatient mortality rate was 6.8% for all subjects. Multivariable analyses demonstrated that age ≥ 70 years was an independent predictor of mortality (OR 3.16, 95% CI 2.77-3.60), whereas instrumented surgery (multivariable OR 0.38, 95% CI 0.28-0.52) and vertebroplasty or kyphoplasty (OR 0.27, 95% CI 0.17-0.45) were associated with decreased odds of death. In surviving patients, both older age (OR 0.32, 95% CI 0.30-0.34) and instrumented fusion (OR 0.37, 95% CI 0.33-0.41) were associated with decreased odds of discharge to home. CONCLUSIONS The present study confirms that lumbar surgery in the elderly is associated with increased morbidity. In particular, instrumented fusion is associated with periprocedural complications, prolonged hospitalization, and a decreased likelihood of being discharged home. However, fusion surgery is also associated with reduced mortality. Age alone should not be an exclusionary factor in identifying surgical candidates for instrumented lumbar spinal fusion. Future studies are needed to confirm these findings.
目的 胸腰椎创伤性骨折是常见损伤,约占所有脊柱创伤的90%。老年人腰椎创伤是一个日益严重的公共卫生问题,指导临床管理的证据相对较少。作者旨在描述老年腰椎创伤性骨折患者手术和非手术治疗相关的并发症、发病率和死亡率。方法 作者利用国家创伤数据库的国家样本计划,对年龄≥55岁的腰椎创伤性骨折患者进行回顾性分析。该组分为中年(55 - 69岁)和老年(≥70岁)队列。队列再细分为非手术、椎体成形术或后凸成形术、非内固定手术和内固定手术。采用单变量和多变量分析来描述和识别每个亚组中医疗和手术并发症、死亡率、住院时间、重症监护病房住院时间、呼吸机使用天数和出院情况的预测因素。报告调整后的优势比、平均差异及相关的95%置信区间。在p < 0.05水平评估统计学显著性,并对每个结局分析应用Bonferroni多重比较校正。结果 在2003年至2012年期间,22835人符合纳入标准,全国范围内代表94103例事件。分析显示各年龄组之间的医疗和手术并发症情况相似。最常见的医疗并发症是肺炎(7.0%)、急性呼吸窘迫综合征(3.6%)和深静脉血栓形成(3%)。手术部位感染发生率为6.3%。内固定手术与每种并发症的最高发生率相关(p < 0.001)。所有受试者的住院死亡率为6.8%。多变量分析表明,年龄≥70岁是死亡率的独立预测因素(OR 3.16,95% CI 2.77 - 3.60),而内固定手术(多变量OR 0.38,95% CI 0.28 - 0.52)和椎体成形术或后凸成形术(OR 0.27,95% CI 0.17 - 0.45)与死亡几率降低相关。在存活患者中,年龄较大(OR 0.32,95% CI 0.30 - 0.34)和内固定融合(OR 0.37,95% CI 0.33 - 0.41)均与回家出院几率降低相关。结论 本研究证实老年腰椎手术与发病率增加相关。特别是,内固定融合与围手术期并发症、住院时间延长以及回家出院可能性降低相关。然而,融合手术也与死亡率降低相关。年龄本身不应成为确定老年腰椎内固定融合手术候选者的排除因素。需要进一步研究来证实这些发现。