Kelly Rachel S, Roulland Sandrine, Morgado Ester, Sungalee Stéphanie, Jouve Nathalie, Tumino Rosario, Krogh Vittorio, Panico Salvatore, Polidoro Silvia, Masala Giovanna, Sánchez María-José, Chirlaque Maria-Dolores, Sala Núria, Gurrea Aurelio Barricarte, Dorronsoro Miren, Travis Ruth C, Riboli Elio, Gunter Marc, Murphy Neil, Vermeulen Roel, Bueno-de-Mesquita H B, Peeters Petra H, Trichopoulou Antonia, Trichopoulos Dimitrios, Lagiou Pagona, Nieters Alexandra, Canzian Federico, Kaaks Rudolf, Boeing Heiner, Weiderpass Elisabete, Stocks Tanja, Melin Beatrice, Overvad Kim, Tjønneland Anne, Olsen Anja, Brennan Paul, Johansson Mattias, Nadel Bertrand, Vineis Paolo
MRC/PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus Norfolk Place, London, W2 1PG, UK.
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Cancer Causes Control. 2015 Dec;26(12):1845-55. doi: 10.1007/s10552-015-0677-2. Epub 2015 Sep 30.
The strong association between t(14;18) translocation and follicular lymphoma (FL) is well known. However, the determinants of this chromosomal aberration and their role in t(14;18) associated FL remain to be established.
t(14;18) frequency within the B cell lymphoma 2 major breakpoint region was determined for 135 incident FL cases and 251 healthy controls as part of a nested case-control study within the European Prospective Investigation into Cancer cohort. Quantitative real-time PCR was performed in DNA extracted from blood samples taken at recruitment. The relationship between prevalence and frequency of the translocation with baseline anthropometric, lifestyle, and dietary factors in cases and controls was determined. Unconditional logistic regression was used to explore whether the risk of FL associated with these factors differed in t(14;18)(+) as compared to t(14;18)(-) cases.
Among incident FL cases, educational level (χ(2) p = 0.021) and height (χ(2) p = 0.025) were positively associated with t(14;18) prevalence, and cases with high frequencies [t(14;18)(HF)] were significantly taller (t test p value = 0.006). These findings were not replicated in the control population, although there were a number of significant associations with dietary variables. Further analyses revealed that height was a significant risk factor for t(14;18)(+) FL [OR 6.31 (95% CI 2.11, 18.9) in the tallest versus the shortest quartile], but not t(14;18)(-) cases.
These findings suggest a potential role for lifestyle factors in the prevalence and frequency of the t(14;18) translocation. The observation that the etiology of FL may differ by t(14;18) status, particularly with regard to height, supports the subdivision of FL by translocation status.
t(14;18)易位与滤泡性淋巴瘤（FL）之间的强关联是众所周知的。然而，这种染色体畸变的决定因素及其在与t(14;18)相关的FL中的作用仍有待确定。
作为欧洲癌症前瞻性调查队列中一项巢式病例对照研究的一部分，对135例新发FL病例和251名健康对照者测定了B细胞淋巴瘤2主要断裂点区域内的t(14;18)频率。对招募时采集的血样提取的DNA进行定量实时PCR。确定病例和对照者中该易位的患病率和频率与基线人体测量学、生活方式和饮食因素之间的关系。采用无条件逻辑回归来探讨与这些因素相关的FL风险在t(14;18)(+)病例与t(14;18)(-)病例中是否存在差异。
在新发FL病例中，教育水平（χ(2) p = 0.021）和身高（χ(2) p = 0.025）与t(14;18)患病率呈正相关；高频[t(14;18)(HF)]病例显著更高（t检验p值 = 0.006）。这些发现未在对照人群中得到重复，尽管存在一些与饮食变量的显著关联。进一步分析显示，身高是t(14;18)(+) FL的显著危险因素[最高四分位数与最低四分位数相比，比值比为6.31（95%置信区间2.11, 18.9）]，但在t(14;18)(-)病例中并非如此。
这些发现表明生活方式因素在t(14;18)易位的患病率和频率中可能发挥作用。FL的病因可能因t(14;18)状态而异，尤其是在身高方面，这一观察结果支持根据易位状态对FL进行细分。
