索拉非尼治疗伴有冯·希佩尔-林道病患者的复发性T1期双侧肾细胞癌：病例报告及文献综述
Sorafenib treatment for recurrent stage T1 bilateral renal cell carcinoma in patients with Von Hippel- Lindau disease: A case report and literature review.
作者信息
Choi Kyung Hwa, Yu Young Dong, Kang Moon Hyung, Park Dong Soo
机构信息
Department of Urology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
出版信息
Can Urol Assoc J. 2015 Sep-Oct;9(9-10):E651-3. doi: 10.5489/cuaj.2863. Epub 2015 Sep 9.
Abstract
Renal cell carcinoma (RCC) with Von Hippel-Lindau (VHL) syndrome is associated with multiple recurrences and a young age at diagnosis. Therefore the primary goal of treatment is to stabilize the disease, minimizing the surgical resection and preserving the renal function in the patients with VHL who have developing RCC nodules after initial treatment. This is the first case report of VHL disease, with long-term stable disease, treated with a half dose of sorafenib after surgical resection and radiofrequency ablation for multiple recurrent stage T1 masses. We discuss the efficacy and safety of low-dose sorafenib treatment and review RCC in a patient with VHL disease.
摘要
伴有冯·希佩尔-林道（VHL）综合征的肾细胞癌（RCC）与多次复发及诊断时年龄较轻有关。因此，治疗的主要目标是稳定病情，在初次治疗后出现RCC结节的VHL患者中尽量减少手术切除并保留肾功能。这是首例VHL病患者的病例报告，该患者在对多个复发性T1期肿块进行手术切除和射频消融后，接受半剂量索拉非尼治疗，病情长期稳定。我们讨论了低剂量索拉非尼治疗的疗效和安全性，并对一名VHL病患者的RCC进行了回顾。
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