Du Dajiang, Sugita Norihiko, Liu Zhen, Moriguchi Yu, Nakata Ken, Myoui Akira, Yoshikawa Hideki
Department of Orthopedic Surgery, Sino-Russian Institute of Hard Tissue Development and Regeneration, Harbin Medical University, Harbin, China ; Department of Orthopedic Surgery, Osaka University, Suita, Japan.
Department of Orthopedic Surgery, Osaka University, Suita, Japan.
Cartilage. 2015 Oct;6(4):241-51. doi: 10.1177/1947603515591628.
To investigate the feasibility of repairing osteochondral defects of critical size by performing mosaicplasty using multiple sliced costal cartilage grafts, which enables repair of extensively injured knees using grafts from a single rib.
Critical osteochondral defects were prepared on the femoral groove of skeletally mature Japanese white rabbits. Costal cartilage grafts from a single rib were harvested and sliced into multiple segments (approximately 3-5 mm in length). The defects were left untreated or repaired by performing mosaicplasty using costal cartilage grafts (with or without a longitudinal cut along the middle). At 4 and 12 weeks after transplantation, International Cartilage Repair Society macroscopic and histological grading was performed.
The macroscopic score and visual histological score were significantly higher in the repaired groups than in the untreated group at 4 and 12 weeks after surgery. Histological continuous integration between grafted costal cartilage and host bone was observed in both repaired groups.
The findings suggest that costal cartilage might be a useful alternative source for chondral grafting. We were able to repair large osteochondral defects by performing mosaicplasty using multiple sliced costal cartilage grafts from a single rib.
探讨使用多片肋软骨移植进行镶嵌成形术修复临界尺寸骨软骨缺损的可行性，该方法能够利用单根肋骨的移植物修复广泛损伤的膝关节。
在骨骼成熟的日本白兔的股骨沟制备临界骨软骨缺损。采集单根肋骨的肋软骨移植物并切成多个节段（长度约3 - 5毫米）。缺损不做处理或通过使用肋软骨移植物（有或没有沿中间纵向切割）进行镶嵌成形术修复。移植后4周和12周，进行国际软骨修复协会宏观和组织学评分。
术后4周和12周，修复组的宏观评分和视觉组织学评分显著高于未处理组。在两个修复组中均观察到移植的肋软骨与宿主骨之间的组织学连续整合。
研究结果表明，肋软骨可能是软骨移植的一种有用替代来源。我们能够通过使用来自单根肋骨的多片肋软骨移植物进行镶嵌成形术修复大的骨软骨缺损。
