Tehrani Neda Mazahery, Riazi-Esfahani Hamid, Jafarzadehpur Ebrahim, Mirzajani Ali, Talebi Hossein, Amini Abdulrahim, Mazloumi Mehdi, Roohipoor Ramak, Riazi-Esfahani Mohammad
Department of Optometry, Faculty of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.
Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
J Ophthalmic Vis Res. 2015 Apr-Jun;10(2):165-71. doi: 10.4103/2008-322X.163773.
To evaluate multifocal electroretinogram (mfERG) changes in eyes with diabetic macular edema (DME) and investigate any possible correlation with optical coherence tomography (OCT) features and visual acuity (VA).
Twenty-nine right eyes of 29 subjects with DME due to non-proliferative diabetic retinopathy and 30 eyes of 30 normal subjects were evaluated. All patients underwent a complete ophthalmic examination. Sixty-one scaled hexagon mfERG responses were recorded. Components of the first order kernel of N1, N2, and P1 in five concentric rings centered on the fovea, were measured in both groups. Correlation and regression analyses were performed among VA, central macular thickness (CMT) based on OCT, mfERG amplitude, and latency of the N1, N2 and P1 waves.
Significant differences were observed in all mfERG parameters in five-ring regions of the retina between eyes with DME versus controls (P < 0.05). There were significant correlations among VA with N2 (P = 0,001, b = 0.73) and P1 amplitudes (P = 0.001, b = -0.84) in the central macular area, and there was a borderline association between VA and CMT (P = 0.042, b = 0.392).
Amplitudes of mfERG components (N1, P1, and N2) are significantly reduced and their latencies are delayed in eyes with DME indicating functional impairment in the outer retina. The mfERG total amplitude was significantly correlated with VA even more than CMT, therefore the combined use of OCT and mfERG for macular evaluation may better evaluate visual status in DME patients.
评估糖尿病性黄斑水肿（DME）患者眼的多焦视网膜电图（mfERG）变化，并研究其与光学相干断层扫描（OCT）特征及视力（VA）之间的可能相关性。
对29例因非增殖性糖尿病视网膜病变导致DME患者的29只右眼和30例正常受试者的30只眼进行评估。所有患者均接受了全面的眼科检查。记录61个标准化六边形mfERG反应。在两组中测量以中央凹为中心的五个同心环中N1、N2和P1一阶核的成分。对VA、基于OCT的中心黄斑厚度（CMT）、mfERG振幅以及N1、N2和P1波的潜伏期进行相关性和回归分析。
DME患眼与对照组相比，视网膜五环区域的所有mfERG参数均存在显著差异（P < 0.05）。在中心黄斑区，VA与N2振幅（P = 0.001，b = 0.73）和P1振幅（P = 0.001，b = -0.84）之间存在显著相关性，VA与CMT之间存在临界相关性（P = 0.042，b = 0.392）。
DME患眼中mfERG成分（N1、P1和N2）的振幅显著降低，潜伏期延迟，表明外层视网膜存在功能损害。mfERG总振幅与VA的相关性甚至比与CMT的相关性更强，因此联合使用OCT和mfERG进行黄斑评估可能能更好地评估DME患者的视觉状态。
