Budni Josiane, Bellettini-Santos Tatiani, Mina Francielle, Garcez Michelle Lima, Zugno Alexandra Ioppi
Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil.
Aging Dis. 2015 Oct 1;6(5):331-41. doi: 10.14336/AD.2015.0825. eCollection 2015 Sep.
Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF). These strong relationship between aging and AD is important to investigate the time which they overlap, as well as, the pathophysiological mechanism in each event. Considering that aging and AD are related to cognitive impairment, here we discuss the involving these neurotrophic factors in the aging process and AD.
衰老是一个伴随着认知能力下降的正常生理过程。这个衰老过程一直是诸如阿尔茨海默病（AD）等与衰老相关疾病发生的主要危险因素。认知缺陷与神经营养因子水平的改变有关，如脑源性神经营养因子（BDNF）、神经生长因子（NGF）和胶质细胞源性神经营养因子（GDNF）。衰老与AD之间的这些紧密关系对于研究它们重叠的时间以及每个事件中的病理生理机制很重要。鉴于衰老和AD都与认知障碍有关，在此我们讨论这些神经营养因子在衰老过程和AD中的作用。
