高混合胰岛素
High-mix insulins.
作者信息
Kalra Sanjay, Farooqi Mohammad Hamed, El-Houni Ali E
机构信息
Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India.
Dubai Diabetes Center, Dubai Health Authority, Dubai, United Arab Emirates.
出版信息
Indian J Endocrinol Metab. 2015 Sep-Oct;19(5):686-90. doi: 10.4103/2230-8210.163214.
Abstract
Premix insulins are commonly used insulin preparations, which are available in varying ratios of different molecules. These drugs contain one short- or rapid-acting, and one intermediate- or long-acting insulin. High-mix insulins are mixtures of insulins that contain 50% or more than 50% of short-acting insulin. This review describes the clinical pharmacology of high-mix insulins, including data from randomized controlled trials. It suggests various ways, in which high-mix insulin can be used, including once daily, twice daily, thrice daily, hetero-mix, and reverse regimes. The authors provide a rational framework to help diabetes care professionals, identify indications for pragmatic high-mix use.
摘要
预混胰岛素是常用的胰岛素制剂，有不同分子比例的产品。这些药物含有一种短效或速效胰岛素以及一种中效或长效胰岛素。高混胰岛素是指短效胰岛素含量为50%或超过50%的胰岛素混合物。本综述描述了高混胰岛素的临床药理学，包括来自随机对照试验的数据。文中提出了多种使用高混胰岛素的方法，包括每日一次、每日两次、每日三次、异质混合和反向给药方案。作者提供了一个合理的框架，以帮助糖尿病护理专业人员确定实际使用高混胰岛素的适应症。
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Efficacy and safety of stepwise introduction of insulin lispro mix 50 in Japanese patients with type 2 diabetes inadequately controlled by oral therapy.胰岛素赖脯混合 50 在口服药物治疗控制不佳的日本 2 型糖尿病患者中的疗效和安全性。
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