Amine peroxides as potential antimalarials.
作者信息
Vennerstrom J L
机构信息
Department of Medicinal Chemistry, Walter Reed Army Institute of Research, Washington, D.C. 20307.
出版信息
J Med Chem. 1989 Jan;32(1):64-7. doi: 10.1021/jm00121a013.
PMID:2642554
Abstract
Six model amine peroxides (4-9) were synthesized as targeted antimalarial oxidants. They were approximately 1 order of magnitude more potent than tert-butyl hydroperoxide (3) in vitro against Plasmodium falciparum, but like 3, they were inactive in vivo against Plasmodium berghei.
摘要
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