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肺动脉肉瘤:一种罕见疾病。

Pulmonary Artery Sarcoma: A Rare Entity.

作者信息

Shomaf Maha, Obeidat Nathir, Al-Fares Fatin, Najjar Saleh

机构信息

The University of Jordan, Department of Pathology.

The University of Jordan, Department of Internal Medicine.

出版信息

J Investig Med High Impact Case Rep. 2014 Apr 3;2(1):2324709614529416. doi: 10.1177/2324709614529416. eCollection 2014 Jan-Mar.

DOI:10.1177/2324709614529416
PMID:26425600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4528857/
Abstract

Pulmonary artery sarcomas (PAS) are extremely rare sarcomas of uncertain histogenesis that often mimic pulmonary thromboemboli. This is a report of a 60-year-old female patient who presented with recurrent chest pain and cough. The patient was first diagnosed with pulmonary embolism but she did not improve on anticoagulant therapy. Follow-up imaging studies revealed a mass in the left hilar region extending into the pulmonary trunk and branches of the left pulmonary artery. The tru-cut biopsy revealed an undifferentiated sarcoma. The patient died 10 months after her initial presentation.

摘要

肺动脉肉瘤(PAS)是一种组织发生不确定的极其罕见的肉瘤,常酷似肺血栓栓塞症。本文报告一名60岁女性患者,她反复出现胸痛和咳嗽。该患者最初被诊断为肺栓塞,但抗凝治疗后病情并未改善。后续影像学检查显示左肺门区有一肿块,延伸至肺动脉主干及左肺动脉分支。粗针活检显示为未分化肉瘤。该患者在首次就诊后10个月死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/cf25965ffbb8/10.1177_2324709614529416-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/5f1fd12e2adb/10.1177_2324709614529416-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/a68d06ade18f/10.1177_2324709614529416-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/9466f42c57af/10.1177_2324709614529416-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/c0c2d7e00dcd/10.1177_2324709614529416-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/47bd31030bec/10.1177_2324709614529416-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/a4be8b286420/10.1177_2324709614529416-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/cf25965ffbb8/10.1177_2324709614529416-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/5f1fd12e2adb/10.1177_2324709614529416-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/a68d06ade18f/10.1177_2324709614529416-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/9466f42c57af/10.1177_2324709614529416-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/c0c2d7e00dcd/10.1177_2324709614529416-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/47bd31030bec/10.1177_2324709614529416-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/a4be8b286420/10.1177_2324709614529416-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/046c/4528857/cf25965ffbb8/10.1177_2324709614529416-fig7.jpg

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本文引用的文献

1
RUNX-1 and CD44 as markers of resident stem cell derivation in undifferentiated intimal sarcoma of pulmonary artery.RUNX-1 和 CD44 作为肺动脉未分化内膜肉瘤中固有干细胞来源的标志物。
Histopathology. 2012 Oct;61(4):737-43. doi: 10.1111/j.1365-2559.2012.04241.x.
2
Variants in folate pathway genes as modulators of genetic instability and lung cancer risk.叶酸代谢途径基因变异作为遗传不稳定性和肺癌风险的调节剂。
Genes Chromosomes Cancer. 2011 Jan;50(1):1-12. doi: 10.1002/gcc.20826.
3
Intimal sarcoma of the pulmonary artery with retrograde extension into the pulmonic valve and right ventricle.
肺动脉内膜肉瘤伴逆行延伸至肺动脉瓣和右心室。
Tex Heart Inst J. 2007;34(1):119-21.
4
Pulmonary artery sarcoma: a case report of surgical cure and 5-year follow-up.肺动脉肉瘤:手术治愈及5年随访的病例报告
Chest. 2002 Aug;122(2):745-7. doi: 10.1378/chest.122.2.745.