Fleischer D E, Goldberg S B, Browning T H, Cooper J N, Friedman E, Goldner F H, Keeffe E B, Smith L E
Division of Gastroenterology, Georgetown University Hospital, Washington, DC 20007.
JAMA. 1989 Jan 27;261(4):580-5.
Colorectal cancer is the second most common cause of cancer in the United States. The overall mortality rate approaches 60%. However, the detection of early lesions results in a mortality rate of 20% or less. Therefore, if improvement in survival is to occur, increased efforts need to be focused not only on primary prevention but also on early detection of malignant lesions and the eradication of potentially malignant lesions. There is no universal consensus as to how this can be accomplished. The purpose of this article is to serve as a guideline, providing a practical basis for improving early detection and management of colorectal cancer and its precursors.
结直肠癌是美国第二大常见癌症病因。总体死亡率接近60%。然而，早期病变的检测可使死亡率降至20%或更低。因此，若要提高生存率，不仅需要加大一级预防力度，还需着重于恶性病变的早期检测以及根除潜在恶性病变。对于如何实现这一点，尚无普遍共识。本文旨在提供一份指南，为改善结直肠癌及其癌前病变的早期检测与管理提供切实可行的依据。
