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Immunosuppression via Tenascin-C.

作者信息

Bellone Matteo, Caputo Sara, Jachetti Elena

机构信息

Division of Immunology, Transplantation and Infectious Diseases, Cellular Immunology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

出版信息

Oncoscience. 2015 Aug 21;2(8):667-8. doi: 10.18632/oncoscience.210. eCollection 2015.

DOI:10.18632/oncoscience.210
PMID:26425650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4580052/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8260/4580052/e0ed0f6bf6bd/oncoscience-02-667-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8260/4580052/e0ed0f6bf6bd/oncoscience-02-667-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8260/4580052/e0ed0f6bf6bd/oncoscience-02-667-g001.jpg

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2
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Tenascin C in colorectal cancer stroma is a predictive marker for liver metastasis and is a potent target of miR-198 as identified by microRNA analysis.结直肠癌基质中的肌腱蛋白C是肝转移的预测标志物,并且是通过微小RNA分析确定的miR-198的有效靶点。
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Galectin-3 in Prostate Cancer Stem-Like Cells Is Immunosuppressive and Drives Early Metastasis.半乳糖凝集素-3 在前列腺癌干细胞样细胞中具有免疫抑制作用,并促进早期转移。
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MicroRNA signature in the chemoprevention of functionally-enriched stem and progenitor pools (FESPP) by Active Hexose Correlated Compound (AHCC).

本文引用的文献

1
Tenascin-C Protects Cancer Stem-like Cells from Immune Surveillance by Arresting T-cell Activation.Tenascin-C 通过阻止 T 细胞激活来保护癌症干细胞样细胞免受免疫监视。
Cancer Res. 2015 May 15;75(10):2095-108. doi: 10.1158/0008-5472.CAN-14-2346. Epub 2015 Mar 25.
2
Gene signatures distinguish stage-specific prostate cancer stem cells isolated from transgenic adenocarcinoma of the mouse prostate lesions and predict the malignancy of human tumors.基因特征可区分从转基因小鼠前列腺腺癌病变中分离的特定阶段前列腺癌干细胞,并预测人类肿瘤的恶性程度。
Stem Cells Transl Med. 2013 Sep;2(9):678-89. doi: 10.5966/sctm.2013-0041. Epub 2013 Jul 24.
3
活性己糖相关化合物 (AHCC) 对功能富集的干细胞和祖细胞池 (FESPP) 的化学预防中的 microRNA 特征。
Cancer Biol Ther. 2017 Oct 3;18(10):765-774. doi: 10.1080/15384047.2017.1373211. Epub 2017 Sep 8.
Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses.
前列腺癌干细胞是先天性免疫和适应性免疫的靶点,并引发肿瘤特异性免疫反应。
Oncoimmunology. 2013 May 1;2(5):e24520. doi: 10.4161/onci.24520. Epub 2013 Apr 16.
4
Prostate cancer, tumor immunity and a renewed sense of optimism in immunotherapy.前列腺癌、肿瘤免疫与免疫治疗的新乐观主义
Cancer Immunol Immunother. 2012 Apr;61(4):453-68. doi: 10.1007/s00262-012-1216-6. Epub 2012 Feb 14.
5
EMT and dissemination precede pancreatic tumor formation. EMT 和播散先于胰腺肿瘤形成。
Cell. 2012 Jan 20;148(1-2):349-61. doi: 10.1016/j.cell.2011.11.025.
6
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs.乳腺癌细胞产生 tenascin C 作为转移生态位组成部分以在肺部定植。
Nat Med. 2011 Jun 26;17(7):867-74. doi: 10.1038/nm.2379.
7
Radical prostatectomy versus watchful waiting in early prostate cancer.根治性前列腺切除术与早期前列腺癌的观察等待。
N Engl J Med. 2011 May 5;364(18):1708-17. doi: 10.1056/NEJMoa1011967.
8
Two positive nodes represent a significant cut-off value for cancer specific survival in patients with node positive prostate cancer. A new proposal based on a two-institution experience on 703 consecutive N+ patients treated with radical prostatectomy, extended pelvic lymph node dissection and adjuvant therapy.对于淋巴结阳性的前列腺癌患者,两个阳性淋巴结代表癌症特异性生存的显著临界值。一项基于两家机构对703例接受根治性前列腺切除术、扩大盆腔淋巴结清扫术和辅助治疗的连续N+患者的经验提出的新建议。
Eur Urol. 2009 Feb;55(2):261-70. doi: 10.1016/j.eururo.2008.09.043. Epub 2008 Oct 1.