通过腱生蛋白-C实现免疫抑制。 - Suppr

Immunosuppression via Tenascin-C.

作者信息

Bellone Matteo, Caputo Sara, Jachetti Elena

机构信息

Division of Immunology, Transplantation and Infectious Diseases, Cellular Immunology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

出版信息

Oncoscience. 2015 Aug 21;2(8):667-8. doi: 10.18632/oncoscience.210. eCollection 2015.

DOI:10.18632/oncoscience.210

PMID:26425650

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4580052/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8260/4580052/e0ed0f6bf6bd/oncoscience-02-667-g001.jpg

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Immunosuppression via Tenascin-C.通过腱生蛋白-C实现免疫抑制。

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本文引用的文献

Tenascin-C Protects Cancer Stem-like Cells from Immune Surveillance by Arresting T-cell Activation.Tenascin-C 通过阻止 T 细胞激活来保护癌症干细胞样细胞免受免疫监视。

Cancer Res. 2015 May 15;75(10):2095-108. doi: 10.1158/0008-5472.CAN-14-2346. Epub 2015 Mar 25.

Gene signatures distinguish stage-specific prostate cancer stem cells isolated from transgenic adenocarcinoma of the mouse prostate lesions and predict the malignancy of human tumors.基因特征可区分从转基因小鼠前列腺腺癌病变中分离的特定阶段前列腺癌干细胞，并预测人类肿瘤的恶性程度。

Stem Cells Transl Med. 2013 Sep;2(9):678-89. doi: 10.5966/sctm.2013-0041. Epub 2013 Jul 24.

Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses.前列腺癌干细胞是先天性免疫和适应性免疫的靶点，并引发肿瘤特异性免疫反应。

Oncoimmunology. 2013 May 1;2(5):e24520. doi: 10.4161/onci.24520. Epub 2013 Apr 16.

Prostate cancer, tumor immunity and a renewed sense of optimism in immunotherapy.前列腺癌、肿瘤免疫与免疫治疗的新乐观主义

Cancer Immunol Immunother. 2012 Apr;61(4):453-68. doi: 10.1007/s00262-012-1216-6. Epub 2012 Feb 14.

EMT and dissemination precede pancreatic tumor formation. EMT 和播散先于胰腺肿瘤形成。

Cell. 2012 Jan 20;148(1-2):349-61. doi: 10.1016/j.cell.2011.11.025.

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs.乳腺癌细胞产生 tenascin C 作为转移生态位组成部分以在肺部定植。

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Immunosuppression via Tenascin-C.

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