Sampath Venkatesh, Helbling Daniel, Menden Heather, Dimmock David, Mulrooney Neil P, Murray Jeffrey C, Dagle John M, Garland Jeffery S
*Department of Pediatrics, Medical College of Wisconsin †Children's Research Institute, Children's Hospital and Health Systems, Milwaukee, WI ‡Children's Hospitals and Clinics of Minnesota, Minneapolis §Department of Pediatrics, Iowa Children's Hospital, University of Iowa, Iowa City ¶Department of Pediatrics, Wheaton Franciscan Health Care, St Joseph Hospital, Milwaukee, WI.
J Pediatr Gastroenterol Nutr. 2016 Mar;62(3):420-3. doi: 10.1097/MPG.0000000000000988.
Reactive oxygen species mediate intestinal injury in necrotizing enterocolitis (NEC), and yet the contribution of antioxidant response (ARE) gene polymorphisms to NEC risk remains unknown. Premature infants recruited in a multicenter study were genotyped for 6 ARE variants. Among 637 infants, 52 had NEC, and 22 developed surgical NEC. Gestational age <28 weeks (P < 0.02) and African American race (P = 0.03) were associated with NEC. The NFE2L2 (rs6721961), SOD2 (rs4880), GSTP1 (rs1695), NQO1 (rs1800566), GCLC (rs17883901), and HMOX1 (rs2071747) variants were not associated with medical or surgical NEC. This study does not support a role for common deleterious ARE variants in NEC.
活性氧介导坏死性小肠结肠炎（NEC）中的肠道损伤，然而抗氧化反应（ARE）基因多态性对NEC风险的影响尚不清楚。在一项多中心研究中招募的早产儿对6种ARE变体进行了基因分型。在637名婴儿中，52名患有NEC，22名发展为外科手术性NEC。胎龄<28周（P<0.02）和非裔美国人种族（P=0.03）与NEC相关。NFE2L2（rs6721961）、SOD2（rs4880）、GSTP1（rs1695）、NQO1（rs1800566）、GCLC（rs17883901）和HMOX1（rs2071747）变体与非手术性NEC无关。这项研究不支持常见有害ARE变体在NEC中的作用。
