DOT1L: a new therapeutic target for aggressive breast cancer.
作者信息
Lee Jeong-Yeon, Kong Gu
机构信息
Department of Pathology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
出版信息
Oncotarget. 2015 Oct 13;6(31):30451-2. doi: 10.18632/oncotarget.5860.
Abstract
摘要
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Targeting Histone Methyltransferase DOT1L by a Novel Psammaplin A Analog Inhibits Growth and Metastasis of Triple-Negative Breast Cancer.新型沙马普明A类似物靶向组蛋白甲基转移酶DOT1L可抑制三阴性乳腺癌的生长和转移。
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本文引用的文献
1
DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression.在乳腺癌进展过程中，DOT1L与c-Myc-p300复合物协同作用，通过表观遗传方式解除对CDH1转录因子的抑制。
Nat Commun. 2015 Jul 22;6:7821. doi: 10.1038/ncomms8821.
2
Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L.组蛋白甲基转移酶DOT1L对Wnt信号靶基因表达的调控
ACS Chem Biol. 2015 Jan 16;10(1):109-14. doi: 10.1021/cb500668u. Epub 2014 Nov 10.
3
Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer.组蛋白H3K79甲基化的抑制选择性地抑制乳腺癌的增殖、自我更新和转移潜能。
Oncotarget. 2014 Nov 15;5(21):10665-77. doi: 10.18632/oncotarget.2496.
4
The emerging roles of DOT1L in leukemia and normal development.DOT1L 在白血病和正常发育中的新兴作用。
Leukemia. 2014 Nov;28(11):2131-8. doi: 10.1038/leu.2014.169. Epub 2014 May 23.
5
The epigenetics of epithelial-mesenchymal plasticity in cancer.癌症中上皮-间充质可塑性的表观遗传学。
Nat Med. 2013 Nov;19(11):1438-49. doi: 10.1038/nm.3336. Epub 2013 Nov 7.
6
lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs.lncRNA 依赖的雄激素受体调控基因激活程序的机制。
Nature. 2013 Aug 29;500(7464):598-602. doi: 10.1038/nature12451. Epub 2013 Aug 14.
7
The diverse functions of Dot1 and H3K79 methylation.Dot1 和 H3K79 甲基化的多种功能。
Genes Dev. 2011 Jul 1;25(13):1345-58. doi: 10.1101/gad.2057811.
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