Lu Na, Yuan Ye, Piao Jinhua, Pei Fei, Sun Kai, Zheng Yang, Hui Ru-Tai
Clin Lab. 2015;61(8):1033-41. doi: 10.7754/clin.lab.2015.150107.
The genetic background associated with the dysregulation of orthostatic blood pressure remains poorly understood. The sympathetic nervous system plays a pivotal role in the regulation of blood pressure, as well as in response to positional changes. The essential role of adrenergic receptors in the sympathetic nervous system prompted us to hypothesize that common genetic variants of the α2-adrenergic receptor might contribute to the dysregulation of orthostatic blood pressure in general populations. This study is to explore the association between the polymorphisms of the α2-adrenergic receptor genes and the occurrence of orthostatic hypotension in Chinese populations.
The polymorphisms ADRA2A C-1291G (rs1800544), ADRA2B 301-303 I/D (rs28365031), and ADRA2C 322-325 I/D (rs61767072) were genotyped in 317 patients with orthostatic hypotension and 664 age- and gender-matched controls. Logistic regression analyses, adjusted for multiple comparisons, were used to determine the association between the allele/genotype of each ADRA2 gene and the risk of orthostatic hypotension.
No significant association was found between the ADRA2A C-1291G, ADRA2B 301-303 I/D, and ADRA2C 322-325 I/D polymorphisms and orthostatic hypotension.
We concluded that the common polymorphisms in the alpha2-adrenergic receptor gene is not associated with orthostatic hypotension risk in Chinese.
与体位性血压调节异常相关的遗传背景仍知之甚少。交感神经系统在血压调节以及对体位变化的反应中起关键作用。肾上腺素能受体在交感神经系统中的重要作用促使我们推测，α2-肾上腺素能受体的常见基因变异可能导致普通人群体位性血压调节异常。本研究旨在探讨中国人群中α2-肾上腺素能受体基因多态性与体位性低血压发生之间的关联。
对317例体位性低血压患者和664例年龄及性别匹配的对照者进行ADRA2A基因C-1291G（rs1800544）、ADRA2B基因301-303 I/D（rs28365031）和ADRA2C基因322-325 I/D（rs61767072）多态性的基因分型。采用经多重比较校正的逻辑回归分析来确定每个ADRA2基因的等位基因/基因型与体位性低血压风险之间的关联。
未发现ADRA2A基因C-1291G、ADRA2B基因301-303 I/D和ADRA2C基因322-325 I/D多态性与体位性低血压之间存在显著关联。
我们得出结论，α2-肾上腺素能受体基因的常见多态性与中国人体位性低血压风险无关。
