Ahmann D L, Creagan E T, Hahn R G, Edmonson J H, Bisel H F, Schaid D J
Mayo Medical School, Rochester, MN.
Cancer. 1989 Jan 15;63(2):224-7. doi: 10.1002/1097-0142(19890115)63:2<224::aid-cncr2820630203>3.0.co;2-i.
Five hundred three patients with advanced malignant melanoma were exposed to a number of clinical investigative chemotherapeutic regimens between 1971 and 1984 in an effort to assess the clinical activity of these regimens in this disease. Of the 503 patients participating in the studies, ten patients experienced a complete response. However, only three of these patients survived more than 5 years. Of this group of 503 patients, seven additional patients who did not experience a complete response survived more than five years. Of the ten patients surviving more than 5 years, two had immediate progression after institution of investigative regimens, whereas five remained stable for brief periods of time before progressive metastatic disease. Three patients experienced a complete response. It appeared that systemic therapeutic interventions in these trials were conspicuously ineffective for this large group of patients. A few long-term survivors attest to the capricious nature of this neoplasm and its association with likely spontaneous regressions. Although these long-term survivors did survive after institution of systemic chemotherapy, it is likely that this survival was related temporally, but perhaps not causally, to the institution of treatment.
1971年至1984年间，503例晚期恶性黑色素瘤患者接受了多种临床研究性化疗方案，以评估这些方案对该疾病的临床活性。在参与研究的503例患者中，有10例患者出现完全缓解。然而，这些患者中只有3例存活超过5年。在这组503例患者中，另外7例未出现完全缓解的患者存活超过了5年。在存活超过5年的10例患者中，2例在采用研究性方案后立即出现病情进展，而5例在出现进行性转移性疾病之前短时间内病情保持稳定。3例患者出现完全缓解。在这些试验中，全身治疗干预措施对这一大组患者显然无效。少数长期存活者证明了这种肿瘤的反复无常的性质及其与可能的自发消退的关联。虽然这些长期存活者在接受全身化疗后确实存活了下来，但这种存活可能在时间上与治疗的实施有关，但也许没有因果关系。
