通过刺激线粒体修复利用PGC-1α和PGC-1β保护视网膜的潜在用途。
The Potential Use of PGC-1α and PGC-1β to Protect the Retina by Stimulating Mitochondrial Repair.
作者信息
Abrahan Carolina, Ash John D
机构信息
Department of Environmental Horticulture Research, University of Florida, Gainesville, FL 32611-0670, USA.
Department of Ophthalmology, University of Florida, ARB-RG232, 1600 SW Archer Rd, 32610, Gainesville, FL, USA.
出版信息
Adv Exp Med Biol. 2016;854:403-9. doi: 10.1007/978-3-319-17121-0_53.
Damage to mitochondria is a common mechanism of cell death in inherited neurodegenerative disorders. Therefore, mitochondrial protection and mitochondrial repair are promising strategies to induce retinal neuroprotection. Peroxisome proliferator-activated receptor γ coactivator-α (PGC-1α) and β (PGC-1β) are transcriptional coactivators that are the main regulators of mitochondrial biogenesis. We propose that PGC-1α and PGC-1β could play a role in regulating retina cell survival, and may be important therapeutic targets to prevent retinal degeneration.
线粒体损伤是遗传性神经退行性疾病中细胞死亡的常见机制。因此，线粒体保护和线粒体修复是诱导视网膜神经保护的有前景的策略。过氧化物酶体增殖物激活受体γ共激活因子-α（PGC-1α）和-β（PGC-1β）是转录共激活因子，是线粒体生物发生的主要调节因子。我们提出，PGC-1α和PGC-1β可能在调节视网膜细胞存活中发挥作用，并且可能是预防视网膜变性的重要治疗靶点。
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