Yang X, Gao L, Wu X, Zhang Y, Zang D
Department of Neurology, Tianjin First Center Hospital of Tianjin Medical University, Tianjin, China.
Department of Neurology, Tianjin First Center Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Acta Neurol Scand. 2016 Aug;134(2):94-100. doi: 10.1111/ane.12513. Epub 2015 Oct 2.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with complicated pathogenesis. No effective diagnostic test and cure exists for the disease at present. We detected the levels of MIP-1α in cerebrospinal fluid (CSF) and serum and then further evaluated whether MIP-1α levels correlate with the severity and progression of ALS.
We used ELISAs to detect MIP-1α levels from 58 patients with ALS and 45 age- and gender-matched controls. The patients with ALS were also clinically evaluated with the revised ALS functional rating scale (ALSFRS-r). Moreover, we followed up with 40 cases of ALS by way of call or clinic visit 4 years after enrollment in this study. Finally, we assessed the correlations between MIP-1α levels and various clinical parameters.
We found that the levels of MIP-1α in patients with ALS significantly increased compared to controls and they were positively correlated with duration. MIP-1α showed negative correlations with disease progression rate and the decrease in ALSFRS-r. Furthermore, the cumulative survival of patients with ALS with high levels of MIP-1α exceeded patients with low MIP-1α levels.
MIP-1α levels increased in both CSF and serum of patients with ALS, and it may be a potential neuroprotective biomarker in ALS.
肌萎缩侧索硬化症（ALS）是一种发病机制复杂的进行性神经退行性疾病。目前尚无针对该疾病的有效诊断测试和治愈方法。我们检测了脑脊液（CSF）和血清中MIP-1α的水平，然后进一步评估MIP-1α水平是否与ALS的严重程度和进展相关。
我们使用酶联免疫吸附测定法（ELISA）检测了58例ALS患者和45例年龄及性别匹配的对照者的MIP-1α水平。还使用修订的ALS功能评定量表（ALSFRS-r）对ALS患者进行了临床评估。此外，在本研究入组4年后，我们通过电话或门诊随访了40例ALS患者。最后，我们评估了MIP-1α水平与各种临床参数之间的相关性。
我们发现，与对照组相比，ALS患者的MIP-1α水平显著升高，且与病程呈正相关。MIP-1α与疾病进展率和ALSFRS-r的下降呈负相关。此外，MIP-1α水平高的ALS患者的累积生存率超过了MIP-1α水平低的患者。
ALS患者的脑脊液和血清中MIP-1α水平均升高，它可能是ALS中一种潜在的神经保护生物标志物。
