[N-烷基咪唑对辣根过氧化物酶催化邻联茴香胺氧化的影响]
[Effect of N-alkylimidazoles on oxidation of o-dianizidine catalyzed by horseradish peroxidase].
作者信息
Lebedeva O V, Dombrovskiĭ V A, Ugarova N N, Berezin I V
出版信息
Biokhimiia. 1978;43(4):696-701.
PMID:26428
Abstract
Effect of a number of N-alkylimidazoles (from N-methyl to N-octylimidazole) on peroxidase oxidation of o-dianizidine at pH 8.0 is studied. Alkylimidazoles studied are found to activate the reaction under given conditions, the activation type being non-competitive KA and (alpha) values are similar for all the activators, which suggests a similar mechanism of their action. Similar KA values suppose an insignificant role of hydrophobic interactions in the binding of N-alkylimidazoles with the enzyme.
摘要
研究了多种N-烷基咪唑（从N-甲基咪唑到N-辛基咪唑）在pH 8.0条件下对邻联茴香胺过氧化物酶氧化反应的影响。研究发现，所研究的烷基咪唑在给定条件下可激活该反应，激活类型为非竞争性，所有激活剂的KA和(α)值相似，这表明它们的作用机制相似。相似的KA值表明疏水相互作用在N-烷基咪唑与酶的结合中作用不显著。
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