两种三相口服避孕药在使用1年期间对女性碳水化合物代谢的影响。

The effects of two triphasic oral contraceptives on carbohydrate metabolism in women during 1 year of use.

作者信息

Spellacy W N, Ellingson A B, Tsibris J C

机构信息

Department of Obstetrics and Gynecology, University of Illinois College of Medicine, Chicago.

出版信息

Fertil Steril. 1989 Jan;51(1):71-4. doi: 10.1016/s0015-0282(16)60431-4.

DOI:10.1016/s0015-0282(16)60431-4

PMID:2642814

Abstract

Sixty-one women were randomly assigned to use one of two different triphasic oral contraceptives (OCs), for one year's time (Ortho Novum 777, Ortho Pharmaceutical Corp., Raritan, NJ, and Triphasil, Wyeth Laboratories, Philadelphia, PA), containing the progestins norethindrone and levonorgestrel, respectively. The carbohydrate metabolism was evaluated using the oral glucose tolerance test before OC use and at the end of the 12th month. Both plasma glucose and insulin levels were measured. The fasting glucose value in the norethindrone-containing OC group (777) was significantly lower at the 1-year testing. All other values were unchanged. These data demonstrate that the triphasic oral contraceptive preparations currently in use have minimal effects on carbohydrate metabolism.

摘要

61名女性被随机分配使用两种不同的三相口服避孕药（OCs）中的一种，为期一年（分别为Ortho Novum 777，由新泽西州拉里坦的Ortho制药公司生产；以及Triphasil，由宾夕法尼亚州费城的惠氏实验室生产），这两种药分别含有炔诺酮和左炔诺孕酮两种孕激素。在使用口服避孕药之前和第12个月末，通过口服葡萄糖耐量试验评估碳水化合物代谢情况。同时测量血浆葡萄糖和胰岛素水平。在为期1年的测试中，含炔诺酮的口服避孕药组（777）的空腹血糖值显著降低。所有其他值均未改变。这些数据表明，目前使用的三相口服避孕药制剂对碳水化合物代谢的影响极小。