果胶与大量元素和微量元素的络合。Na、Fe 和 Na、Ca、Fe 配合物的抗贫血活性。
Complexation of pectin with macro- and microelements. Antianemic activity of Na, Fe and Na, Ca, Fe complexes.
机构信息
A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, Arbuzov Str. 8, Kazan, 420088, Russia.
A.E. Arbuzov Institute of Organic and Physical Chemistry of Kazan Scientific Center of Russian Academy of Sciences, Arbuzov Str. 8, Kazan, 420088, Russia.
出版信息
Carbohydr Polym. 2015 Dec 10;134:524-33. doi: 10.1016/j.carbpol.2015.07.034. Epub 2015 Jul 22.
New water-soluble pectin complexes with Ca(2+), Mg(2+), Co(2+), Cu(2+), Fe(2+), Mn(2+), Zn(2+) on the basis of pectin biopolymer have been synthesized and successfully tested on white rats. For a starting, we have obtained a sodium pectate to enhance solubility of target complexes as a whole. Shortly afterwards, running the reaction of ligand exchange of Nа(+) ions with corresponding s-, d- metal cations we were able to synthesize new pectin complexes. The ranges of s-, d-metals salts concentrations were detected experimentally, in which the selective formation of water-soluble complexes occurred. Antianemic effect of new pectin complexes with Na, Fe and Na, Ca, Fe was investigated on white rats with posthemorrhagic anemia. Under the effect of complexes, the improvement of animals and prevention of erythropoiesis disorders were observed. Antianemic effect of the complexes manifested itself in the doses equivalent to 25% or 50% of the iron daily rate, recommended in the treatment of iron-deficiency anemia with the drugs based on iron sulphate.
已合成了基于果胶生物聚合物的新的水溶性果胶与 Ca(2+)、Mg(2+)、Co(2+)、Cu(2+)、Fe(2+)、Mn(2+)、Zn(2+)的复合物，并在大白鼠身上成功进行了测试。首先，我们得到了一种果胶酸钠，以提高目标复合物的整体水溶性。随后，通过对 Na(+)离子与相应的 s、d 金属阳离子进行配体交换反应，我们能够合成新的果胶复合物。实验检测到了 s、d 金属盐浓度的范围，在此范围内发生了水溶性复合物的选择性形成。用缺铁性贫血的大白鼠研究了新的果胶复合物（Na、Fe 和 Na、Ca、Fe）的抗贫血效果。在复合物的作用下，观察到动物状况的改善和防止红细胞生成障碍。复合物的抗贫血作用表现在相当于推荐的硫酸亚铁药物治疗缺铁性贫血的铁日剂量的 25%或 50%的剂量。
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