抗 CD137（4-1BB）单克隆抗体的治疗潜力。
Therapeutic potential of anti-CD137 (4-1BB) monoclonal antibodies.
机构信息
a 1 Tulane University, Section of Clinical Immunology, Allergy and Rheumatology, Department of Medicine , New Orleans, LA 70112, USA.
b 2 Cell and Immunobiology, and R & D Center for Cancer Therapeutics, National Cancer Center , Goyang 410-769, Korea ;
出版信息
Expert Opin Ther Targets. 2016;20(3):361-73. doi: 10.1517/14728222.2016.1091448. Epub 2015 Oct 1.
INTRODUCTION
4-1BB (CD137) is an important T-cell stimulating molecule. The 4-1BB mAb or its variants have shown remarkable therapeutic activity against autoimmunity, viral infections, and cancer. Antibodies to 4-1BB have recently entered clinical trials for the treatment of cancer with favorable toxicity profile. In this article, we present a review documenting the efficacy and pitfalls of 4-1BB therapy.
AREAS COVERED
An extensive literature search has been made on 4-1BB, spanning two decades, and a comprehensive report is presented here highlighting the origins, biological effects, therapeutic potential, and mechanistic basis of targeting 4-1BB as well as the side effects associated with such therapy.
EXPERT OPINION
Research so far indicates that 4-1BB is highly protective against various pathological conditions including cancer. However, a few important side effects of 4-1BB therapy such as liver toxicity, thrombocytopenia, anemia, and suppressive effects on certain immune competent cells should be taken into consideration before it is used for human therapy.
简介
4-1BB（CD137）是一种重要的 T 细胞刺激分子。4-1BB mAb 或其变体在治疗自身免疫、病毒感染和癌症方面显示出显著的治疗活性。针对 4-1BB 的抗体最近已进入癌症治疗的临床试验，具有良好的毒性特征。本文综述了 4-1BB 治疗的疗效和陷阱。
涵盖的领域
对 4-1BB 进行了广泛的文献检索，跨越了二十年，并在此基础上提出了一份全面的报告，重点介绍了靶向 4-1BB 的起源、生物学效应、治疗潜力和机制基础，以及与这种治疗相关的副作用。
专家意见
到目前为止的研究表明，4-1BB 对包括癌症在内的各种病理状况具有高度的保护作用。然而，在将其用于人类治疗之前，应该考虑到 4-1BB 治疗的一些重要副作用，如肝毒性、血小板减少、贫血和对某些免疫功能细胞的抑制作用。
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