Li Qilin, Zhang Hongbin
Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, No 2, North Cuihu Road, Kunming, Yunnan 650091 (P. R. China).
Chemistry. 2015 Nov 9;21(46):16379-82. doi: 10.1002/chem.201503594. Epub 2015 Oct 2.
In this paper, a new strategy towards the synthesis of codeine and morphine is reported. This new approach features a cascade cyclization to construct the dihydrofuran ring, and an intramolecular palladium catalyzed C-H olefination of unactivated aliphatic alkene to install the morphinan ring system.
本文报道了一种合成可待因和吗啡的新策略。这种新方法的特点是通过串联环化构建二氢呋喃环，以及通过分子内钯催化未活化脂肪族烯烃的C-H烯基化反应来构建吗啡喃环系。
