MioLab，一种大鼠心肌收缩力模拟器：在心脏细胞生理学和生物物理学教学中的应用。

MioLab, a rat cardiac contractile force simulator: Applications to teaching cardiac cell physiology and biophysics.

机构信息

Research and Technology Center of Mogi das Cruzes University, Mogi das Cruzes, Brazil.

出版信息

Comput Methods Programs Biomed. 2015 Dec;122(3):480-90. doi: 10.1016/j.cmpb.2015.09.012. Epub 2015 Sep 21.

DOI:10.1016/j.cmpb.2015.09.012

PMID:26428599

Abstract

INTRODUCTION

Understanding the basic concepts of physiology and biophysics of cardiac cells can be improved by virtual experiments that illustrate the complex excitation-contraction coupling process in cardiac cells. The aim of this study is to propose a rat cardiac myocyte simulator, with which calcium dynamics in excitation-contraction coupling of an isolated cell can be observed. This model has been used in the course "Mathematical Modeling and Simulation of Biological Systems". In this paper we present the didactic utility of the simulator MioLab(®).

METHODS

The simulator enables virtual experiments that can help studying inhibitors and activators in the sarcoplasmic reticulum sodium-calcium exchanger, thus corroborating a better understanding of the effects of medications, which are used to treat arrhythmias, on these compartments. The graphical interfaces were developed not only to facilitate the use of the simulator, but also to promote a constructive learning on the subject, since there are animations and videos for each stage of the simulation. The effectiveness of the simulator was tested by a group of graduate students.

RESULTS

Some examples of simulations were presented in order to describe the overall structure of the simulator. Part of these virtual experiments became an activity for Biomedical Engineering graduate students, who evaluated the simulator based on its didactic quality. As a result, students answered a questionnaire on the usability and functionality of the simulator as a teaching tool. All students performed the proposed activities and classified the simulator as an optimal or good learning tool. In their written questions, students indicated as negative characteristics some problems with visualizing graphs; as positive characteristics, they indicated the simulator's didactic function, especially tutorials and videos on the topic of this study.

CONCLUSIONS

The results show that the simulator complements the study of the physiology and biophysics of the cardiac cell.

摘要

简介

通过虚拟实验可以更好地理解心脏细胞的生理学和生物物理学基本概念，这些实验可以说明心脏细胞中复杂的兴奋-收缩耦联过程。本研究旨在提出一个大鼠心肌细胞模拟器，通过该模拟器可以观察到兴奋-收缩耦联过程中的钙离子动力学。该模型已用于“生物系统的数学建模与模拟”课程中。在本文中，我们展示了 MioLab（®）模拟器的教学实用性。

方法

该模拟器支持虚拟实验，可以帮助研究肌浆网钠钙交换体的抑制剂和激活剂，从而更好地理解药物对这些隔室的作用，这些药物被用于治疗心律失常。图形界面不仅被开发用于方便使用模拟器，而且还可以促进对该主题的建设性学习，因为在模拟的每个阶段都有动画和视频。一组研究生对模拟器的有效性进行了测试。

结果

为了描述模拟器的整体结构，呈现了一些模拟示例。这些虚拟实验的一部分成为生物医学工程研究生的一项活动，他们根据其教学质量对模拟器进行了评估。结果，学生们根据可用性和作为教学工具的功能回答了一份关于模拟器的问卷。所有学生都完成了建议的活动，并将模拟器评为最佳或良好的学习工具。在他们的书面问题中，学生们指出了一些可视化图表的问题作为负面特征；将模拟器的教学功能，特别是关于本研究主题的教程和视频，作为正面特征。