Robertson R P, Franklin G, Nelson L
Department of Medicine, University of Minnesota, Minneapolis 55455.
Diabetes. 1989 Jan;38 Suppl 1:99-100. doi: 10.2337/diab.38.1.s99.
Cyclosporin or placebo was administered in a randomized, double-blind fashion to 13 patients with multiple sclerosis for 1 yr to determine whether cyclosporin adversely affects glucose homeostasis or beta-cell function. No significant differences were observed in fasting glucose, fasting insulin, intravenous glucose tolerance, or glucose-induced insulin secretion before treatment or at 3 wk, 6 mo, or 1 yr during treatment. Longer therapeutic trials with larger patient groups will be necessary to decide whether cyclosporin can be safely given for many years without risk of developing diabetes mellitus.
以随机、双盲方式对13例多发性硬化症患者给予环孢素或安慰剂，为期1年，以确定环孢素是否会对葡萄糖稳态或β细胞功能产生不利影响。治疗前及治疗期间3周、6个月或1年时，空腹血糖、空腹胰岛素、静脉葡萄糖耐量或葡萄糖诱导的胰岛素分泌均未观察到显著差异。需要对更多患者群体进行更长时间的治疗试验，以确定环孢素是否能多年安全给药而无患糖尿病的风险。
