Kornbluth Sally, Fissore Rafael
Duke University School of Medicine, Durham, North Carolina 27710.
University of Massachusetts, Amherst, Veterinary and Animal Sciences, Amherst, Massachusetts 01003.
Cold Spring Harb Perspect Biol. 2015 Oct 1;7(10):a006064. doi: 10.1101/cshperspect.a006064.
Vertebrate reproduction requires a myriad of precisely orchestrated events-in particular, the maternal production of oocytes, the paternal production of sperm, successful fertilization, and initiation of early embryonic cell divisions. These processes are governed by a host of signaling pathways. Protein kinase and phosphatase signaling pathways involving Mos, CDK1, RSK, and PP2A regulate meiosis during maturation of the oocyte. Steroid signals-specifically testosterone-regulate spermatogenesis, as does signaling by G-protein-coupled hormone receptors. Finally, calcium signaling is essential for both sperm motility and fertilization. Altogether, this signaling symphony ensures the production of viable offspring, offering a chance of genetic immortality.
脊椎动物的繁殖需要无数精确协调的事件——特别是，母体产生卵母细胞，父体产生精子，成功受精，以及早期胚胎细胞分裂的启动。这些过程由许多信号通路控制。涉及Mos、CDK1、RSK和PP2A的蛋白激酶和磷酸酶信号通路在卵母细胞成熟过程中调节减数分裂。类固醇信号——特别是睾酮——调节精子发生，G蛋白偶联激素受体的信号传导也是如此。最后，钙信号对于精子运动和受精都至关重要。总之，这种信号交响曲确保了有活力后代的产生，提供了遗传不朽的机会。
