Chen Li-Ping, Li Chuan, Wen Tian-Fu, Yan Lu-Nan, Li Bo, Yang Jia-Yin
Li-Ping Chen, Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu-610041, China. Department of Liver Surgery & Liver Transplantation, West China Hospital of Sichuan University, Chengdu-610041, China.
Chuan Li, Department of Liver Surgery & Liver Transplantation, West China Hospital of Sichuan University, Chengdu-610041, China.
Pak J Med Sci. 2015 Jul-Aug;31(4):763-9. doi: 10.12669/pjms.314.7523.
To compare the outcomes of living donor liver transplantation (LDLT) versus deceased donor liver transplantation (DDLT) for patients with hepatocellular carcinoma (HCC) in different selection criteria.
Data of patients with HCC who underwent liver transplantation between 2005 and 2013 at our center were reviewed. Clinical data of LDLT recipients and DDLT recipients were compared. The postoperative recurrence-free survival (RFS) rate and overall survival (OS) rate after LDLT versus DDLT were compared in the Milan recipients, the University of California, San Francisco (UCSF) recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients.
Data of 255 patients were retrospectively reviewed in this study. Seventeen DDLT recipient and 9 LDLT recipients died during the perioperative period. Among the remaining 229 recipients (NLDLT=66, NDDLT=163), 96 patients met the Milan criteria, 123 recipients met the UCSF criteria, 135 patients met the up-to-seven criteria, 216 patients met the Hangzhou criteria, and 229 recipients met the Chengdu criteria. The overall RFS and OS rates of the Milan recipients, the UCSF recipients, the up-to-seven recipients, the Hangzhou recipients and the Chengdu recipients after LDLT and DDLT were all similar.
Using well-studied selection criteria, LDLT offers similar outcomes to DDLT for patient with HCC, even using expanded selection criteria.
比较在不同选择标准下，活体供肝肝移植（LDLT）与尸体供肝肝移植（DDLT）治疗肝细胞癌（HCC）患者的疗效。
回顾了2005年至2013年在本中心接受肝移植的HCC患者的数据。比较了LDLT受者和DDLT受者的临床数据。对米兰标准受者、加利福尼亚大学旧金山分校（UCSF）标准受者、七标准受者、杭州标准受者和成都标准受者中LDLT与DDLT后的术后无复发生存（RFS）率和总生存（OS）率进行了比较。
本研究回顾性分析了255例患者的数据。17例DDLT受者和9例LDLT受者在围手术期死亡。在其余229例受者中（NLDLT = 66，NDDLT = 163），96例患者符合米兰标准，123例受者符合UCSF标准，135例患者符合七标准，216例患者符合杭州标准，229例受者符合成都标准。LDLT和DDLT后，米兰标准受者、UCSF标准受者、七标准受者、杭州标准受者和成都标准受者的总体RFS率和OS率均相似。
采用经过充分研究的选择标准，即使使用扩大的选择标准，LDLT治疗HCC患者的疗效与DDLT相似。
