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骶骨脊索瘤的外科治疗:典型病例与当前治疗模式

Surgical Management of Sacral Chordomas: Illustrative Cases and Current Management Paradigms.

作者信息

Pendharkar Arjun V, Ho Allen L, Sussman Eric S, Desai Atman

机构信息

Department of Neurosurgery, Stanford University School of Medicine.

出版信息

Cureus. 2015 Aug 12;7(8):e301. doi: 10.7759/cureus.301.

DOI:10.7759/cureus.301
PMID:26430575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4571900/
Abstract

Sacral chordomas represent more than 50% of all sacral tumors. These slow-growing, malignant lesions present insidiously and are often large and intimately involved with sacral neurovascular and pelvic structures. En bloc resection is the only well-established predictor of progression-free survival. Optimal surgical management requires a complex multi-disciplinary approach. Here, we describe two cases of sacral chordoma and review current management paradigms.

摘要

骶骨脊索瘤占所有骶骨肿瘤的50%以上。这些生长缓慢的恶性病变起病隐匿,通常体积较大,并与骶骨神经血管及盆腔结构紧密相连。整块切除是无进展生存期唯一已明确的预测指标。最佳的手术治疗需要复杂的多学科方法。在此,我们描述两例骶骨脊索瘤病例并回顾当前的治疗模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21be/4571900/32fd766daa57/cureus-0007-000000000301-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21be/4571900/89aced8d3ba9/cureus-0007-000000000301-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21be/4571900/932490d8cd3d/cureus-0007-000000000301-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21be/4571900/32fd766daa57/cureus-0007-000000000301-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21be/4571900/89aced8d3ba9/cureus-0007-000000000301-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21be/4571900/932490d8cd3d/cureus-0007-000000000301-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21be/4571900/32fd766daa57/cureus-0007-000000000301-i03.jpg

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本文引用的文献

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Prognostic Factors in the Operative Management of Sacral Chordomas.骶骨脊索瘤手术治疗中的预后因素
World Neurosurg. 2015 Nov;84(5):1354-61. doi: 10.1016/j.wneu.2015.06.030. Epub 2015 Jun 23.
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Can local recurrence of a sacral chordoma be treated by further surgery?骶骨脊索瘤的局部复发可以通过进一步手术治疗吗?
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Preliminary results of high-dose single-fraction radiotherapy for the management of chordomas of the spine and sacrum.脊柱和骶骨脊索瘤高剂量单次分割放疗的初步结果。
Neurosurgery. 2013 Oct;73(4):673-80; discussion 680. doi: 10.1227/NEU.0000000000000083.
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Chordoma: current concepts, management, and future directions.脊索瘤:当前概念、管理和未来方向。
Lancet Oncol. 2012 Feb;13(2):e69-76. doi: 10.1016/S1470-2045(11)70337-0.
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Long-term results: adjuvant radiotherapy in en bloc resection of sacrococcygeal chordoma is advisable.长期疗效:整块切除骶骨脊索瘤后辅助放疗是可行的。
Spine (Phila Pa 1976). 2011 May 1;36(10):E656-61. doi: 10.1097/BRS.0b013e3181f8d1f3.
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Survival of patients with malignant primary osseous spinal neoplasms: results from the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2003.恶性原发性骨脊柱肿瘤患者的生存率:来自 1973 年至 2003 年监测、流行病学和最终结果(SEER)数据库的结果。
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